Scientists have identified a subtype of human fat cells that respond to insulin stimulation

At present, researchers are not very clear about the contribution of cell structure heterogeneity and architecture to the function of white adipose tissue (WAT), and it is well known that fat cells can affect the body's sensitivity to insulin

Research results show that the overall ability of adipose tissue to respond to insulin is determined by the proportion and function of specific adipocyte subtypes, which may have a certain significance and impact on diseases such as obesity, insulin resistance and type 2 diabetes

In order to test whether these adipocyte subtypes are related to any specific function, the researchers partially examined how these cell subtypes in four individual bodies responded to short-term increases in insulin levels in their bodies.

Image source: Jesper Bäckdahl, et al.

In this research report, the researcher Ryden and others used a technology called spatial transcriptomics (spatial transcriptomics) to conduct related research, which can generate relevant information about the organization structure through a microscope, and can use RNA sequencing technology To generate relevant data on gene expression

In summary, the results of this article show that by tapping multi-channel resources, researchers have identified that human white adipose tissue is composed of three different types of mature adipocytes.

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Original source:

Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, et al.