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    Home > Active Ingredient News > Immunology News > Scientists have made the latest research achievements in the field of hematopoietic stem cell research!

    Scientists have made the latest research achievements in the field of hematopoietic stem cell research!

    • Last Update: 2021-03-05
    • Source: Internet
    • Author: User
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    -JEM: Revealing the effects of aging on the function of hematopoietic stem cells, even transplanting aging hematopoietic stem cells into young bone marrow micro-environments does not really return to old children doi:10.108 4/jem.20192283 by transplanting the elderly hematopoietic stem cells (old HSC) into the bone marrow micro-environment (also translated as bone marrow niche) in young mice, it can be confirmed that the gene expression pattern of the elderly HSC can be restored to the pattern of young hematopoietic stem cells.
    , on the other hand, the function of the elderly HSC did not recover in the young bone marrow micro-environment.
    -year-old HSC's apparent genome (DNA methylation) did not change significantly even in the young bone marrow micro-environment, so DNA methylation spectrum is a better indicator than older HSC gene expression patterns.
    a team led by Professor Atsushi Iwama of the Department of Stem Cell and Molecular Medicine at the Institute of Medical Sciences at the University of Tokyo, Japan, published the world's first studies, which were recently published in the journal Journal of Experiment Medicine.
    Iwama said: "These results will help develop treatments for age-related blood diseases.
    Iwama team looked at whether older HSC would rejuvenate in a young bone marrow micro-environment.
    without pre-treatment, such as irradiation, tens of thousands of elderly hematocytes/progenition cells collected from 20-month-old mice were transplanted into eight-week-old young mice.
    two months of follow-up, they collect bone marrow cells and perform fluid cell analysis.
    Iwama team also transplanted HSC from 10-week-old young mice.
    , the transplanted elderly HSC was isolated and RNA sequence analysis and DNA methylation analysis were performed.
    Photo Source: CC0 Public Domain 6 Cell Rep: Scientists have developed a new method of producing hematopoietic stem cells from an energy source: 10.1016/j.celrep.202 0.108474 In a recent study published in the international journal Cell Reports, scientists from institutions such as the Spanish Genome Control Center and Columbia University identified a special protein that is essential for the amplification of scarce, life-saving blood stem cells.
    Research may help scientists develop new ways to reproduce large numbers of these stem cells in and out of the body, which are currently one of the biggest limitations scientists use in a variety of medical procedures, from treatments for blood cancer to genetic blood disorders that require bone marrow transplants.
    Hematopoietic Stem Cells (HSCs) are responsible for the continuous renewal of blood, producing billions of new cells every day, and HSCs have unlimited potential to self-renew throughout the life cycle of an organism and produce every type of blood cell, including the cells that make up our body's immune system.
    HSCs also have great potential for treating a variety of resoictic cancers, autoimmune diseases and hereditary blood disorders, yet only one in 2,500 cells in the bone marrow is hematopoietic stem cells, a scarcity that may greatly limit the use of hematopoietic stem cells in medical procedures.
    7 Science: Significant Progress! In a new study, researchers at Yale University in the United States discovered a key biological link in the transformation of endosperm cells into hematopoietic stem cells and progenitor cells (HSPC).
    study, published in the December 4, 2020 issue of the journal Science, found that reprogramming cells to HSPC has been the highest goal of an introphy stem cell transplant and a life-saving treatment for blood cancer.
    , little is known about the mechanisms that regulate this shift at the cellular and molecular levels.
    the new study, the authors found a key link between a complex sugar called polysaccharine and endothelial-to-hematopoietic, transition EHT.
    EHT is a process that differentiates from blood-borne endoskin cells to HSPC.
    In the 1960s, biologist Ernest McCulloch, M.D., and biophysicist Dr. James Till discovered that hematopoietic stem cells (HSCs) have the ability to self-renew and eventually produce different types of blood cells, making a breakthrough in stem cell transplantation.
    stem cells can form all the blood cells needed for an entire life.
    8: Cell Stem Cell explained in detail! The mystery of the switch of artificial blood stem cells from latent to active: 10.1016/j.stem.2020.11.001 In a new study, researchers from research institutions such as Princess Margaret Cancer Center in Canada, the University of Toronto and the Ontario Cancer Institute have revealed how hematopoietic stem cells (HSCs) can produce new blood cells in our lifetimes by looking at vast, unknown areas of our genetic material.
    these regions hold important clues to subtle biological changes in these cells.
    the findings were published in the cell Stem Cell journal.
    findings from studying normal blood could be used to enhance hematopoietic stem cell transplants and could provide clues to the process by which cancer cells survive chemotherapy and refore grow after years of treatment.
    this study used state-of-the-art sequencing techniques to analyze the visual genetic landscape of human hematopoietic stem cells, revealing important information on how genes regulate through the three-dimensional folding of chromatin.
    , chromosomes are found in the nucleosomes and are made up of DNA and proteins, which package DNA into a compact structure.
    chromosome structure in the united States are associated with DNA replication, repair, and gene expression (turning genes on or off).
    9 Stem Cell Rep: Heavy! Scientists find super hematopoietic stem cells in human embryos! Its proliferation capacity is 200-500 times that of hematopoietic stem cells in cord blood! Doi:10.1016/j.stemcr.2020.08.008 In a recent study published in the international journal Stem Cell Reports, scientists from the University of Edinburgh and others have discovered a super-potential hematopoietic stem cell in human embryos, commonly known as hematopoietic stem cells (HSCs, hematopoietic cel).
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