Scientists have revealed for the first time the anti-tumor immune function of cell coke death

the findings provide new ideas for the development of cancer immunotherapy drugs, gasdermin family protein has also become a potential biomarker of tumor immunotherapy, and the excitement of these proteins is likely to become a new direction in the development of anti-tumor drugs.
the realization of tumor selective protein function regulation in living bodies is of great significance to life science research and clinical drug development, but it is still a long-standing challenge in the field of chemical biology.
The research shows the advantages of high efficiency and good bio orthopaedicity of the "dual-target activation" strategy based on boron tifluoride desilicon reaction, and on the other hand, it reveals the great potential of the idea of transforming the probe into an activator in activating living proteins.
In the early stages of work, Liu Zhibo's laboratory found that a class of boron amino acid probes (18F-boronine) had significant and specific ingestion of tumors and used them for early diagnosis and precise demarcation of brain tumors in clinical practice.
study, researchers found that boron tropony groups on boronine could be used directly for the removal of silane. On this basis, the researchers constructed a bio orthopaedic shear system mediated by Phe-BF3 at the cellular and living levels, which gave boronine probe activation and achieved tumor selective protein function regulation through the "dual-target activation" strategy. The system is universal, but has an advantage over proteins that need to be selectively released in tumor cells, and gasdermin proteins are an example.
recent studies in the Qifeng laboratory have found that the Gasdermin family protein is the executive molecule of cell coke death. When the Gasdermin protein is activated in the cell, its N-side domain is oligomered into a hole in the cell membrane, which eventually leads to cell lysis death and induces a strong inflammatory response. When the researchers applied the bio orthosis system to the Gasdermin protein, they enabled the tumor to activate cell coke death in place and controlled. Further research has found that causing cell coke death in tumors can induce the body's efficient anti-tumor immune activity, and thus remove tumors. (Source: Cui Xueqin, China Science Daily)
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