Scientists have revealed new mechanisms for DHA to promote neurodevelopment and function in the brain

On May 19th, Cell-Report published a research paper online entitled "Retinol X-subjects α Regulating the in-body mechanism of dendrogen development and functional synapses dependent on DHA", which was completed by yu Xiang Research Group of the Center for Excellence in Brain Science and Intelligent Technology of the Chinese Academy of Sciences (Neuroscience Research Institute) and the National Key Laboratory of Neuroscience. Combined with experiments such as somatic gene manipulation (genetically modified mice, viral injections, embryonic electroplation, etc.), pharmacology, fluorescent dye microinfraction, RNA sequencing, electrophysiology and behavior of brain tablets, the study found that the free DHA in the brain regulates the development of synapses and functional synapses through the signal path of RXRA dependence, analyzes the new mechanism of DHA to promote brain development and function, and provides new ideas for the treatment of related diseases.
the formation of nerve loops is highly dependent on the formation of functional synapses, and the process is regulated by the synergy of signals inside and outside cells. DHA is an important part of neuron membranes -- in the gray area of the cerebral cortical cortical region, 30% to 40% fatty acids of phospholipids are DHA. DHA mainly exists in the plastic membrane phospholipid by esterification, but can also be released from the membrane under the role of phospholipidase, in a free manner or through its derivatives to participate in a variety of signal transduction. Studies have shown that free DHA is an in vivo of retinol X-like (RXR), but there has been a lack of functional association.
the nucleologic subject RXRA has been reported to be associated with cognitive abilities and the development of certain neurological disorders. Numerous studies have shown that the absence of DHA is associated with a variety of neurodevelopmental disorders and neuropsyurological disorders, while DHA supplementation is thought to relieve or treat developmental delays or neuropsyurological disorders, or even to raise awareness among the general population. However, the effects of dietary supplementation of DHA on synactical function and behavior take a long period of time, weeks in mice and months in humans, a far from the time-called effect of adding unested DHA (free DHA) to neurons cultured in-body to promote synhapus-triggered parenting and synapse transmission over hours to days. Therefore, further exploration of DHA's mechanisms for promoting brain development and function is essential to understanding its function of regulating brain development.
based on known phenomena, Yu Xiang's research team proposed the hypothesis that unesterified DHA in the body may regulate neurotic protrusion through its subject, RXRA. By tapping Rxra's Rxra cKO mice in the cerebral cortical layer and hippoctic excitable neurons, a significant decrease in the density of dexragent ratchets in their vertebral neurons was found. They further discovered through a variety of genetic manipulation methods that Rxra's regulation of synapses and functional protrusions is bidirectional, synhapus-mediated, cell-autonomous, and that the function depends on its DNA binding domain. Consistent with RXRA's bidirectional regulation, unesterified DHA brain injection can significantly increase the density of dexterous ratchets, while specific inhibition of the release of DHA significantly reduces the density of dexterous ratchets; In addition, as an important protrusion regulator, the expression of early genes was reduced in Rxra cKO mice, while intra-brain injection of DHA improved the expression of early genes. Finally, they measured the basic behavioral behavior of Rxra cKO mice and found that most of them behaved normally, but with significant abnormalities associated with social memory.
this study provides in-body evidence of DHA and RXRA as a mating-subject combination, regulates the development of synapses and functional synapses, analyzes the new mechanism of DHA to promote brain development and function, and provides new ideas for the treatment of related brain diseases. (Source: Huang Xin Cao Fahua, China Science Journal)
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