Scientists have revealed the dynamic changes in the three-dimensional structure of human embryo chromatin, which can help understand the process of life development.

Exploring the mysteries of human genes has always been a frontier in life science.
two leading scientific research teams in China recently worked together to reveal the dynamic changes of the three-dimensional structure of chromatin in early human embryos, which will help to better understand the process of life development.
related research results have been published in the new issue of the journal Nature. the two scientific research teams in
were led by a member of the Chinese Academy of Sciences, Professor Chen Zijiang of Reproductive Medicine at Shandong University and Professor Liu Jiang of the Beijing Genomics Institute of the Chinese Academy of Sciences.
, the researchers not only revealed the dynamic changes of the chromatin three-dimensional structure in early human embryos, but also found that CTCF protein has an important regulatory effect on the topological domain in early embryonic development.
researchers say the scientific study has analyzed the advanced structure of human sperm and early embryos.
they found that in early human embryonic development, there was genome-wide level of high-level chromatin structural reprogramming, and found that CTCF proteins played a key role in this.
team also found that, unlike sperm from other species, such as mice and macaques, human sperm did not have a topological domain.
they also mapped the chromatin three-dimensional conformation map of early human embryos, which has important theoretical and clinical significance for the deep understanding of the development of early human embryos.
reporters learned that recent research results in the field of life science show that DNA can be organized by folding to form different topological domains, and eventually form a high-level chromatin structure.
high-level chromatin structure is an important epigenetic factor, which is closely related to gene expression regulation.
but the dynamic change of chromatin structure in the development of matching and embryonic embryos has always been a mystery.
therefore, it is of great significance to explore the dynamic changes and mechanisms of chromatin three-dimensional structure in human sperm and early embryos.
Chongqing to explore AI-assisted screening embryo sequester IVF technology in the just concluded 21st Chongqing Assisted Reproductive Medicine Conference, Hualong.com -New Chongqing client reporter was informed that by the city's maternal and child health care hospital, reproductive medicine Chongqing City chief medical expert studio, human embryo engineering Chongqing key laboratory led by the team, will be the first to use artificial intelligence technology to predict embryo chromosome syllitas, its accuracy rate of 70% to 80%, can better screen healthy embryos.
held the first meeting in 1999 on the theme of "single-sperm oocyte intracellular microinjection", Chongqing Assisted Reproductive Medicine Conference has been held for 21 consecutive years, many domestic and foreign industry in this year, to share the exchange of cutting-edge scientific research results.
With the development of technology, new technologies such as non-invasive embryo chromosome screening, single-cell transcription alsome, metabolomics and proteomics have been applied to IVF (i.e., assisted reproductive technology) laboratory technology, and the application of artificial intelligence technology in IVF laboratory technology has also made important breakthroughs.
According to data from the Chongqing Institute of Genetics and Reproduction, the average age of women in Chongqing who conceived the next generation using IVF technology increased year by year in 2015, and in 2017, the average age of women using IVF technology to give birth to the next generation was 33 years.
the number of IVF clinics in the hospital rose from nearly 200,000 to 350,000 in the three years from 2015 to 2017, and the number of IVF patients in the hospital rose from about 10,000 in 2015 to 17,000 in 2017. Huang Guoning, director of the women's and children's health care hospital in
City, said that the goal of modern artificial assisted reproduction is to give birth to healthy children, so from the beginning of the embryo, we should pay attention to its chromosomes.
according to the existing evaluation criteria, doctors through the naked eye observation, but the accuracy rate is only about 50%.
through a creative way to do embryo biopsy, is to detect the embryo chromosome sifts abnormal lying more accurate way, but because there is a invasive test, there is a certain impact on embryo development.
, the institute and the Chinese University of Geology are jointly developing products that use artificial intelligence technology to predict the chromosome sonofness of embryos, and the accuracy rate will reach 70 to 80% through AI pixel recognition.
" pre-implantation genetic diagnostic techniques are now used in clinical practice. Zhang Xiaodong, an associate researcher at the Institute of Genetics and Reproduction of Chongqing Women's and Children's Health Hospital, said the technology is based on IVF, that is, before the embryo has been implanted in the mother's womb, the entire genome amplification technology to obtain the embryo's DNA, the selection of embryos that do not carry the disease-causing gene, so as to avoid pregnancy-related diseases to children.

embryo is a specific reference to sexual reproduction, refers to male reproductive cells and female reproductive cells combined into a joint, after a number of cell division and cell differentiation formed after the ability to develop into a biological formation.
embryorefers to the initial stage of the process of sexual reproduction development, from the first division of the fertilized egg to the beginning of the next stage of developmental biology.
egg cells begin to divide, develop and form into embryos after fertilization.
Source: Xinhua.com, Hualong.com-New Chongqing Client.