Scientists have revealed the mechanisms of a broad-spectrum anti-flu virus in ferro-based nanoenzymes

Peng Daxin told China Science Daily that influenza A virus is a very important human zoozopathic pathogen, which can cause infection and morbidity in people and a variety of animals, and is the main culprit in the influenza pandemic. Because influenza A virus has many subtypes and rapid variation characteristics, often lead to vaccine immune failure or drug resistance. Therefore, it is necessary to study and apply high-efficiency broad-spectrum influenza prevention and control agents.
The catalytic activity of nanoenzymes is comparable to that of natural enzymes, but it is more stable than natural enzymes and has the advantages of multi-functionality and low cost, and has become a frontier hot spot of multidisciplinary cross-cutting in recent years. In this latest study, iron-based nanoenzymes mainly simulate lipid oxidase activity and can inactivate influenza viruses in neutral environments. "This broadens the field of nanoenzyme research and provides a new influenza prevention and control strategy with broad application prospects." Goliding said.Qin Tao, the first author and associate professor of
thesis, said that the mechanism is simply summarized as, after contact with influenza virus particles, the effective catalytic reaction of the virus "bulletproof" cystic membrane lipid peroxide, oxidation products further disintegrate the cell infested cystic hemoglobin protein and neuroineinase protein embedded in the surface of the cystic membrane, resulting in the destruction of influenza virus structure and function, so that the virus invasion and replication capacity is lost.
" iron-based nanoenzyme targets catalytic core substrates for influenza virus lipid cystic membranes, a structure that is highly conservative in a variety of subtypes of influenza viruses, so the agent can achieve broad-spectrum anti-flu virus effect, can efficiently inactivate such as H1N1, H5N1, H7N9 and other 12 more popular subtype influenza viruses. Qin Tao further said.
it is understood that the achievement has been applied for a national invention patent, the future is expected to be widely used in anti-viral masks, high-risk places of air filtration devices, etc. , but also to block the spread of influenza virus between humans and poultry is of great significance.
The research has been funded by the National Key Research and Development Program, the National Natural Science Foundation of China, the Natural Science Foundation of Jiangsu Province, the Center for Collaborative Innovation in the Prevention and Control of Animal Diseases in Jiangsu Province, and the Advantage Disciplines of Jiangsu Province.
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