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    Home > Active Ingredient News > Immunology News > Scientists have shown for the first time that complex tissue can be safely reprogrammed into a younger form...

    Scientists have shown for the first time that complex tissue can be safely reprogrammed into a younger form...

    • Last Update: 2021-01-06
    • Source: Internet
    • Author: User
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    Scientists have successfully reversed the animal's visual aging clock, proving for the first time that complex tissue can be safely reprogrammed into a younger state, as we often call it, according to a new study published in the journal Nature.
    key to these studies is to reprogram cells so that they can gain the genetic function of young cells.
    scientists reprogrammed re-programmed retinal cells in mice to re-regeneration of impaired vision caused by aging, and successfully reversed optic nerve damage caused by glare, while impaired vision was restored.
    the study is that with the development of technology, humans have more possibilities to reverse aging, and there are more new ways to deal with age-related diseases.
    aging poses long-term challenges to global public health Despite the general increase in life expectancy, global population ageing poses long-term challenges to modern medicine and public health.
    as life expectancy increases, so do age-related noncommunicable diseases such as cardiovascular disease, type 2 diabetes, Alzheimer's disease and cancer.
    , in order to avoid age-related health decline, future treatments involving cellular health, systemic aging and age-related diseases and their underlying regulatory mechanisms need to be addressed.
    broadly speaking, aging is a process of cell deterioration and tissue damage accumulation, which leads to decreased organ function and increased sensitivity to age-related diseases.
    cells entering the aging stage are shown to be irreversible, anti-apoptosis-resistant silky schizophrenia, resulting in functional changes in gene expression, chromatin structure, and cell behavior.
    years, regenerative medicine has penetrated more and more widely in the field of anti-aging, anti-aging based on stem cell technology has become a hot research topic, and stem cell-sourced exosomes have become the new mouth in the field of anti-aging.
    aging of the body includes gradual decline in organ function and increased susceptibility to age-related diseases.
    this is associated with a decrease in the number of stem cells in the body and aging, which reduces the ability of stem cells to self-renew, differentiate and regenerate damaged tissues and organs.
    Photo Source: Nature's recent evidence suggests that exosomes play an important role in various processes of aging, such as miRNAs in exosomes, in regulating processes that promote aging, such as cell aging, stem cell failure, telomere length, and circadian rhythms.
    Therefore, further clarification of the molecular mechanisms of stem cell-sourced exosomes in aging may contribute to a better understanding of aging biology, clarify their role in stem cell function, and identify important targets for future regenerative therapies.
    cells play an important role in the steady state, development and repair of tissues and organs by replacing aging or damaged cells.
    Stem cell exosomes contain mRNA, microRNA, proteins, lipids, transcription factors, cytokines, growth factors, and surface molecules, which can be transmitted directly to the target cells through surface subjects, or through direct membrane fusion and endo-swallowing.
    cell communication mediated by exosomes has advantages over side secretion signals and endocrine signals, as each exosome may transmit more than one message and play a regulatory role at different stages of gene expression.
    cell communication mediated by stem cell exosomes is involved in many physiological processes, including immunomodulation, tumor progression, tissue regeneration, reprogramming, differentiation, telomere function, and aging.
    clinical studies have confirmed that exosomes play an anti-aging role in the skin, and that the consequence of aging is a decrease in tissue regeneration potential, which may reflect a decrease in the number of skin stem cells or a decrease in their function.
    Studies have shown that exosomes from interstitial stem cell sources play a role in controlling the proliferation of fibroblasts and endostrote cells at different stages of skin regeneration, and that skin tissue treated by interstitial stem cell exosomes can eventually be better resurricalized and collagen matured at the site of injury, increasing myofibromic cell formation, reducing scarring, and improving burn healing.
    addition, interstitial stem cell exosomes are also used in a variety of aging-related disease treatment studies such as cardiovascular disease, diabetes, osteoarthritis, and so on.
    In the future, there are still many challenges in moving stem cell exosomes from experimental research to clinical transformation: for example, when using stem cell exosomes to combat age-related decline, standardized processes are needed to extract, purify, and quantify exosomes in a timely manner;
    Looking ahead to recent research has highlighted the emerging role of exosomes in the aging process, and in the future, with the synergy of exosomes (lipids, mRNA, non-coding RNA, proteins) in the biological process of aging becoming known, coupled with the continuous validation of exosome-based anti-aging methods in clinical trials, humans may usher in greater breakthroughs in the field of anti-aging.
    Reference 1. Mujib Ullah , Nathan Norton Ng , Waldo Concepcion , Avnesh S Thakor. Emerging role of stem cell-derived extracellular microRNAs in age-associated human diseases and in different therapies of longevity. Ageing Res Rev. 2020 Jan; 57:100979. doi: 10.1016/j.arr.2019.100979.2. A.S. Ahmed, M.H. Sheng, S. Wasnik, D.J. Baylink, K.W. Lau Effect of aging on stem cells World J. Exp. Med., 7 (2017), pp. 1-103. R. Basu, E. Breda, A.L. Oberg, C.C. Powell, C. Dalla Man, A. Basu, J.L. Vittone, G.G. Klee, P. Arora, M.D. Jensen, G. Toffolo, C. Cobelli, R.A. Rizza Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance Diabetes, 52 (2003), pp. 1738-17484.M.A. Baxter, R.F. Wynn, S.N. Jowitt, J.E. Wraith, L.J. Fairbairn, I. Bellantuonoo of Telomere length reveals rapids of human mstron cells, 22 (2004), pppp. 675-6825. J.V. Chakkalakal, K.M. Jones, M.A. Basson, A.S. Brack The aged niche disrupts muscle stem cell quiescence Nature, 490 (2012), pp. 355-3606.T. Furuta, S. Miyaki, H. Ishitobi, T. Ogura, Y. Kato, N. Kamei, K. Miyado, Y. Higashi, M. Ochi Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model Stem Cells Transl. Med., 5 (2016), pp. 1620-1630。
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