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    Home > Biochemistry News > Biotechnology News > Scientists hope to successfully destroy tumor cells that express RAS cancer gene

    Scientists hope to successfully destroy tumor cells that express RAS cancer gene

    • Last Update: 2020-06-02
    • Source: Internet
    • Author: User
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    Photo: Marco Mil?n, IRB Barcelona, the researchers used black belly fruit flies to find that the damage to cell DNA caused by high levels of RAS-induced cell proliferation may be expected to help scientists develop new treatments to specifically eliminate tumor cells that activate RAS expressionThe researchers said that cells that express RAS replicate their DNA quickly, leading to cell errors and DNA damage, and now we have found that RAS blocks cells from repairing damage; in normal cells, cells promote cell death by activating p53 tumor suppressors, but because RAS blocks the ability of tumor suppressors to promote cell death, it is on this basis that researchers are able to use it to develop new gene therapiesresearchers used a drug called Trametinib, a special drug used to treat melanoma in humans, to selectively eliminate malignant tumors without affecting the development of organs or fruit flies themselvesIn addition, the researchers found that radiotherapy, which promotes DNA damage, may also increase the sensitivity of cells that express RAS to gene therapyfinal researcher Milan said the results of this paper promise to help us later combine radiotherapy with RAS inhibitors to selectively kill tumor cells and radically cure canceroriginal origin:Lada Murcia et alSelective Killing of RAS-Malignant Syls by Exploiting Oncogene-Induced DNA Damage, Cell Reports (2019)DOI: 10.1016/j.celrep.2019.06.004
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