Scientists hope to unlock the mysteries of the brain!

September 23, 2020 // -- In a recent study published in the international journal Nature Communications entitled "A spike-timing-dependent plasticity rule for dendritic spines", scientists from the University of Montreal and other institutions have uncovered the molecular mechanisms behind the body's memory and learning abilities, especially how the brain processes, stores and integrates information.
paper, the researchers analyzed the function and morphological transformation of synapses, tiny protrusions located on neuron branches that are thought to be the underlying mechanisms behind brain learning and memory. 'We're very excited because this is the first time we've found the rules of synaptic plasticity, a process directly related to brain memory formation, which allows researchers to understand plasticity and how memory is formed when neurons in the cerebral cortical layer receive a single or multiple stream of sensory information,' said Araya, a researcher at
.
The brain is made up of billions of excited neuron cells that are responsible for communication and information processing; Represented by synapses, the leaves are represented by a tyrule, and these thousands of small leaves act as a channel for receiving excitable information from other cells, which determines whether the information is important enough to be amplified and transmitted to other neuron cells.
Photo Source: Pixabay/CC0 Public Domain This is a key concept, and the same may be true of memory and learning processes during information processing, integration and storage; The neuron's mechanism of amplifying the "volume" is triggered to help hear that particular message; otherwise, the low volume information is further lowered so that it is not noticed, a phenomenon that corresponds to the plasticity of the synapses, which involves an increase or decrease in the intensity of the synapse input.
researchers point out that this is the basic principle of time-dependent plasticity, or discharge timing dependence on plasticity (STDP), which regulates the strength of connections between neurons in the brain and is thought to help promote the brain's memory and learning processes.
Although studies have noted this phenomenon and how neurons are connected, researchers do not yet know the precise structural assembly of destructive ratchets and the rules that control synhapus plasticity.
researchers have now successfully revealed the molecular mechanisms behind STDP.
Until now, no one knew how synapse information input was arranged in the neural tree, and no one knew exactly what caused the synapses to increase or decrease the intensity of their information transmission, and the researchers' goal was to extract the synactical connection rules responsible for building memory in the brain. In the
study, researchers used preclinical models from an early stage, a critical period in brain learning and memory, and used advanced technology in a dual photon microscope to simulate synhapus contact between two neurons, revealing an important pattern associated with the arrangement of information received by tyrups. the
study showed that the information was stored in different ways based on the amount of input received and how close it was, and the researchers said that as the main recipient of other neuron information input, the structure and function of degenerative diseases, such as brittle X-staining, were often directly related to the structure and function of the degenerative disease. Chromosomal syndrome or autism, for example, because patients are unable to process and store information properly, may undermine the logic of brain memory building, and now researchers can develop better adaptive treatments by understanding the molecular mechanisms behind the dynamics of deity and how they affect the function of the nervous system.
() References: Sabrina Tazerart, Diana E Mitchell, Soledad Miranda-Rottmann, et al. A spike-timing-dependent plasticity rule for dendritic spines, Nat Commun. 2020 Aug 26;11 (1):4276. doi:10.1038/s41467-020-17861-7.