Scientists link epigenetic biomarker to gastrointestinal problems in children with autism

In a recent study, David Beversdorf, in collaboration with a Penn State University researcher, identified specific RNA biomarkers associated with gastrointestinal problems in children with autism

They collected saliva samples from nearly 900 children, some with autism and gastrointestinal disorders, at several academic medical centers across the country

"We wanted to understand how children's bodies respond to the various bacteria in the mouth and determine whether these interactions contribute to gastrointestinal symptoms," said an associate professor of pediatrics at Penn State College of Medicine.

Beversdorf added that RNA has regulatory properties throughout the human body, and the specific RNAs identified in the study may have regulatory effects on biological pathways related to metabolism, digestion, depression and addiction

"It's a 'chicken or egg' situation and we still don't know if it's RNA that could cause gastrointestinal problems, or if gastrointestinal problems cause the RNA to express differently, but we've identified a relationship that will help to explore further, " said Beaversdorf, who also holds appointments at the University of Michigan College of Arts and Sciences and the University of Michigan School of Medicine

"Salivary RNA Biomarkers in Gastrointestinal Dysfunction in Children with Autism and Neurodevelopmental Disorders: Potential Implications for Precision Medicine" was recently published in the journal Frontiers in Psychiatry

The NextGen Precision Health Initiative brings together innovators from the University of Missouri and three other research universities in the UM system to pursue life-changing advances in precision health, highlighting the promise of personalized healthcare and the impact of large-scale interdisciplinary collaborations

Journal Reference :

1. David Q.