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    Home > Food News > Nutrition News > Scientists link epigenetic biomarker to gastrointestinal problems in children with autism

    Scientists link epigenetic biomarker to gastrointestinal problems in children with autism

    • Last Update: 2022-04-29
    • Source: Internet
    • Author: User
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    In a recent study, David Beversdorf, in collaboration with a Penn State University researcher, identified specific RNA biomarkers associated with gastrointestinal problems in children with autism
    These findings may one day help us find personalized treatments to ease the suffering of these people


    They collected saliva samples from nearly 900 children, some with autism and gastrointestinal disorders, at several academic medical centers across the country
    After analyzing the samples, the researchers identified specific RNA biomarkers associated with children with autism and experiencing gastrointestinal symptoms


    "We wanted to understand how children's bodies respond to the various bacteria in the mouth and determine whether these interactions contribute to gastrointestinal symptoms," said an associate professor of pediatrics at Penn State College of Medicine.
    Steve Hicks said he collaborated with Beversdorf on the study

    "By identifying these specific microRNAs in the saliva of children with autism, these molecules could be future targets for developing new treatments or tracking the efficacy of drugs in children with autism-related gastrointestinal disorders


    Beversdorf added that RNA has regulatory properties throughout the human body, and the specific RNAs identified in the study may have regulatory effects on biological pathways related to metabolism, digestion, depression and addiction

    "It's a 'chicken or egg' situation and we still don't know if it's RNA that could cause gastrointestinal problems, or if gastrointestinal problems cause the RNA to express differently, but we've identified a relationship that will help to explore further, " said Beaversdorf, who also holds appointments at the University of Michigan College of Arts and Sciences and the University of Michigan School of Medicine
    "This research may help precision medicine one day where we can follow children with autism and gastrointestinal symptoms over time and assess how to respond to individualized treatments, with the ultimate goal of reducing their symptoms and improving their quality of life


    "Salivary RNA Biomarkers in Gastrointestinal Dysfunction in Children with Autism and Neurodevelopmental Disorders: Potential Implications for Precision Medicine" was recently published in the journal Frontiers in Psychiatry
    Funding for this research was provided by the National Institutes of Health

    Co-authors of the study include Kristin Sohl, David Levitskiy, Priscilla Tennant, Robin Goin-Kochel, Rebecca Shaffer, Alexandra Confair and Frank Middleton


    The NextGen Precision Health Initiative brings together innovators from the University of Missouri and three other research universities in the UM system to pursue life-changing advances in precision health, highlighting the promise of personalized healthcare and the impact of large-scale interdisciplinary collaborations
    This is a collaborative effort to harness the power of Missouri's research to create a better future for Missouri's health

    An important part of the plan is its anchor facility, the Roy Blunt Next Generation Precision Medicine Building, which opens in October 2021, expanding collaboration among researchers, clinicians and industry leaders at a state-of-the-art research facility


    Journal Reference :

    1. David Q.
      Beversdorf, Kristin Sohl, David Levitskiy, Priscilla Tennant, Robin P.
      Goin-Kochel, Rebecca C.
      Shaffer, Alexandra Confair, Frank A.
      Middleton, Steven D.
      Saliva RNA Biomarkers of Gastrointestinal Dysfunction in Children With Autism and Neurodevelopmental Disorders: Potential Implications for Precision Medicine .
      Frontiers in Psychiatry , 2022; 12 DOI: 10.

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