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Scientists reveal new mechanisms for epigenetic regulation of rice grain size |
Recently, Song Xianjun’s team, a researcher from the Institute of Botany, Chinese Academy of Sciences, discovered through yeast two-hybrid screening and verification experiments that GRAIN WEIGHT 6a (GW6a), which encodes histone acetylase, interacts with the homologous protein HDR3 of DA1
.
Related research results were published in "Plant Cells"
Rice grain size determines the yield and appearance quality of rice, and is controlled by multiple quantitative trait loci (QTLs); among them, GW6a is a positive regulator of rice grain size and yield
.
At present, the gene regulatory network on which GW6a depends is still unclear
Researchers have found through experimental evidence of rice transgenics that HDR3 is a positive regulator of rice grain size and an ubiquitin receptor with ubiquitin binding activity, which can enhance the ubiquitination level of GW6a
.
After further research, they found that HDR3's ubiquitination modification of GW6a slowed down the 26S proteasome-dependent protein degradation of GW6a, thereby increasing the level of GW6a enzyme activity and enhancing the latter's regulation of the expression of its downstream target genes
In addition, genetic relationship analysis showed that HDR3 is likely to be located upstream of GW6a, playing a function of regulating grain size in the same genetic pathway, and regulating its expression by combining with downstream gene promoters
.
This study reveals a new mechanism for the epigenetic molecular module HDR3-GW6a to regulate rice grain size, and provides a new perspective for in-depth exploration of the molecular regulation mechanism and genetic network of crop seed size
The research was funded by the Chinese Academy of Sciences Strategic Leading Science and Technology Project (Class A), the National Key Research and Development Program, and the National Natural Science Foundation of China
.
(Source: Tian Ruiying, China Science News)Chinese Academy of Sciences
Related paper information: https://doi.
https://doi.
org/10.
1093/plcell/koab194