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    Home > Medical News > Medical Science News > Scientists reveal the mechanism of preimplantation syndrome after cord blood transplantation

    Scientists reveal the mechanism of preimplantation syndrome after cord blood transplantation

    • Last Update: 2021-08-01
    • Source: Internet
    • Author: User
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    The research team of Prof.

    Non-blood cord blood transplantation is an important means to cure hematological malignancies, hematopoietic failure diseases, congenital immunodeficiency diseases and some genetic metabolic diseases, and the incidence of chronic graft-versus-host disease after transplantation is low and mild, and patients The quality of life is high

    The research team analyzed the peripheral blood of recipients after non-blood cord blood transplantation and found that there was a significant increase in peripheral blood mononuclear cells in PES patients.

    On the basis of mechanism research, the clinical team carried out a single-arm open clinical trial of tocilizumab (a monoclonal antibody that specifically blocks IL-6 receptor) in the treatment of severe PES patients, and found that tocilizumab was used for intervention Treatment can significantly control the clinical symptoms of severe PES patients and improve the survival rate of patients

    The research lasted for nearly 8 years, and some of the results have provided important practical guidance significance for the school’s proposal and implementation of an immunotherapy program for severely ill patients with new coronary pneumonia (tocilizumab treatment program)

    Related paper information: https://doi.

    1038/s41467-021-24412-1 https://doi.
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