Scientists reveal trim35 anti-flu virus double mechanism.

Recently, the NationalAvian InfluenzaReference Laboratory of Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences made important progress in the study of the natural immune mechanism of the TRIM family protein against influenza virus, and the relevant research results were published online in Protein and CellThe study found that TRIM35 is a positive regulatory molecule produced by the signaling pathway I (RIG-I) of the vitiric acid-induced gene I (RIG-I) and illustrates the molecular mechanism of TRIM35 inhibiting influenza virus replication and diseasethe study, TRIM35 is a positive regulatory molecule of the natural immune-induced gene I signaling pathway, which can promote the production of type I interferonInvivia experiments further confirmed that the replication titer of influenza virus in the Trim35 gene knockout mice significantly increased, and the pathogenicity significantly increasedin-depth study, on the one hand, TRIM35 through the macro-inseminate gene I signaling pathway of the macro-cyprene modification, and thus promote the formation of VISA-TBK1 complex and type I interferon production, thereby inhibiting influenza virus replicationon the other hand, the influenza virus PB2 protein can inhibit the production of type I IFN by inhibiting the ubiquity modification of TRAF3, but TRIM35 degrades it by causing it to degrade by ubiquitin modification at 736 bits of influenza virus PB2 protein, thereby inhibiting the activity of the viral ribonuclein complex and viral replication, the study found that TRIM35 can play its anti-flu virus role through a dual mechanism, thus deepening the understanding of the host's natural immune system anti-flu virus mechanismDoctoral students Sun Nan and Jiang Li were co-authors of the article, and Chen Hualan, a member of the Chinese Academy of Sciences, and Li Xianjun, a researcher at the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, were the authors of the articleThe research has been funded by the National Key Research and Development Program, the National Natural Science Foundation of China, the Heilongjiang Natural Science Foundation and the Central Public Interest Research Institute for the special project spending of basic scientific research business expenses (
bio-valleyBioon.com).