Scientists shed light on the molecular mechanisms that drive intestinal bacterial imbalances and inflammation.

Biotechnology Channel News: In a study published in the international journal Cell Host and Microbe, scientists from the University of Texas Southwestern Medical Center have uncovered the molecular pathways behind interfering with the balance of gut bacteria during the onset of inflammatory diseases.
researcher Professor Sebastian Winter says a deep understanding of these pathways may help us develop new strategies to prevent or treat a variety of diseases, such as inflammatory bowel disease (IBD), specific gastrointestinal infections, and colorectal cancer.
more than 1 million people in the United States currently suffer from inflammatory bowel disease, a chronic, long-term enteritis disease, and there are no effective treatments and preventive measures.
In this study, researchers explained the key mechanisms behind intestinal changes during enteritis, saying that intestinal inflammation is directly related to changes in nutrients obtained from bacteria in the gut, a healthy human gut is home to a diverse microbiome, the number of gut bacterial cells is about 10 times the number of human cells, and for most of a person's life, the body's microbiome helps promote digestion, protect the body from infection or regulate the development of the body's healthy immune system.
Inflamed bowel disease, gastrointestinal infections, and cancer can be accompanied by an aggressive attack of the gut, while the composition of the gut microbiome is completely disrupted, the number of beneficial bacteria will begin to decrease slowly, and some may even become harmful bacteria, so imbalances in the gut microbiome are thought to accelerate the process of enteritis.
Healthy guts are usually oxygen-deprived, and beneficial bacteria are well adapted to these low-oxygen environments and ferment to break up fiber in food, while harmful bacteria, such as E. coli, tend to "thrive" in high levels of oxygen, as beneficial bacteria do.
Researcher Winter explains that inflammation changes the environment, which in turn interferes with the growth of anaerobic bacteria that live in the gut, but E. coli tends to prefer this environment and often waits for an "accidental event" to occur to start an offensive, such as inflammation of the body.
increased oxygen availability during inflammation can help E. coli survive in the inflammatory intestines.
By breathing, large amounts of waste from beneficial bacteria are recycled by E. coli in the gut, which destroys these metabolic wastes and promotes rapid growth and expansion of the E. coli population.
If it's important to clarify the molecular mechanisms of intestinal bacterioscopic imbalances or to develop new therapies and diagnostic strategies for later scientists, of course, researchers hope to develop more effective strategies for treating inflammatory bowel disease and inflammatory-related colorectal cancers, such as the development of a new drug to inhibit the special metabolic function of E. coli.
'If we interfere with waste production with beneficial symblotic bacteria, we can block the metabolism of harmful bacteria, such as E. coli, which in turn can affect the growth of harmful bacteria, thus protecting the balance of the entire gut microbiome,' said Winter, a researcher.
the most effective strategy is to inhibit the special metabolic effects of E. coli in the gut to avoid its rapid reproduction and side effects on the body's intestines.
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