Scientists succeed in modifying psychedelic compounds so that they are "cured" but not "magical"

When it comes to Ypogain, perhaps many people are strangers.
it is a psychedelic alkaloid, which has a strong anti-addiction effect on both humans and animals.
studies have shown that Ypogain can reduce symptoms of drug suspension, reduce drug cravings and prevent recurrence.
originally a "star drug" for neuropsychemics, but after being sold in France, it was withdrawn from the market due to serious adverse reactions, including toxicity, hallucinogenic effects and arrhythmic disorders.
, Ypogan's potential as a therapeutic agent is limited by several major issues.
, access is limited by overexploitation of plants and the lack of scalable, selective full synthesis.
second, the safety of Ipogain is insulable, and its nonpolar properties cause it to accumulate in adipose tissue and lead to severe heart toxicity.
To this, researchers from the University of California, Davis, have developed a new non-hallucinogenic compound, taberanthalog (TBG), a water-soluble, halogen-free, non-toxic Ipoganoid similar, that can be synthesized step by step and has the potential to treat addiction, depression and other mental illnesses.
results were published in the December 9 issue of nature.
researchers found that giving regular zebrafish larvae Ipogain lowers their heart rate and increases the likelihood of arrhythmic disorders, but TBG does not induce these undesirable esopteriores.
In addition, in toxicity tests for mature zebrafish development, Ipogain (100 m) significantly increased malformations and deaths 2 and 5 days after fertilization, respectively, compared to significantly fewer fish that could not survive due to TBG treatment (100 sM).
data show that TBG is less toxic than Ipogain.
TBG is a safer similar to Ipogain after demonstrating that TBG's safety has improved relative to Ipogain, the researchers then assessed its effect on structural plasticity.
results show that TBG increases the formation of new synapses (branches) in rat nerve cells and the formation of new ratchets on these synapses.
this is similar to the effects of drugs such as ketamine, LSD, MDMA and DMT (the active ingredient in plant extract ayahuasca) on connections between nerve cells.
, however, TBG does not cause convulsions in the head of mice, which are associated with human hallucinations.
TBG Promotes Neuroplasticity To assess the effects of TBG on alcohol intake, the researchers used intermittent, two-bottle selection experiments (20% ethanol (v/v) to simulate alcoholism in humans.
mice experienced repeated cycles of alcoholism and withdrawal over a seven-week period, which led to high ethanol consumption and alcohol-like behavior, resulting in blood alcohol levels equal to those of people with alcohol abuse.
results show that TBG selectively reduces alcohol intake.
The effects of TBG on animal behavior associated with depression, alcohol and substance abuse, in summary, the work, through careful chemical design, modified a psychedelic compound to produce a safer, non-hallucinogenic variant with therapeutic potential, promising new options for people with mental illness.
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