Scientists used a non-toxic Botox drug delivery platform to treat Botox poisoning

Botox is a severe and fatal disease characterized by muscle paralysis.
botulinum toxin is by far the strongest known toxin that can enter motor neurons and block nerve transmission, leading to paralysis.
Because botulinum toxins can efficiently target motor neurons and nerve endings, general therapeutic drugs cannot enter neurons, so once paralysis occurs, you can only wait for these toxins to slowly disappear, there is no better treatment to reverse the process.
Recently, a team of researchers at Harvard Medical School and Boston Children's Hospital developed a drug delivery platform based on non-toxic Botox that can deliver therapeutic drugs inside neurons to relieve the condition.
the study was published in The Science Journal's sub-issue, Translational Medicine, entitled: Delivery of single-domain antibodies into neurons using a chimeric toxin-platform is therapeutic in mouse models of botulism.
researchers developed a delivery platform that is embedded with non-toxic Botox and fuses nanoscale therapeutic antibodies with the delivery platform to form therapeutic proteins, which are then used in Botox-poisoned mice, and found that the therapeutic protein shortens the duration of local muscle paralysis in mice and restores muscle function within hours.
results show that therapeutic nanoantibodies can be delivered to poisoned neurons through new delivery platforms and neutralized Botox in neurons.
the study provided an effective treatment for Botox poisoning after exposure, as well as a new method for the precise delivery of drugs to cells.
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