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    Home > Biochemistry News > Plant Extracts News > Screening Chemical Libraries for Compounds That Affect Protein Sorting to the Yeast Vacuole

    Screening Chemical Libraries for Compounds That Affect Protein Sorting to the Yeast Vacuole

    • Last Update: 2021-01-17
    • Source: Internet
    • Author: User
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    Protein trafficking to the yeast vacuole has been extensively studied using a series of deletion mutants. In these genetic screens, mis-targeted vacuolar cargo proteins were used as phenotype markers. Here we describe a similar approach employing pharmacological effects of diverse chemical compounds to mimic molecular phenotypes caused by conventional genetic mutations in protein trafficking genes.
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