SCRT: Efficacy and safety of stem cells in the treatment of diabetic foot

Background: Diabetes is one of the most common chronic metabolic disorders, with 536.

Current standard regimens for DF therapy include metabolic control and comorbidity therapy, infection treatment, tissue perfusion recovery, local ulcer debridement care, wound dressing, decompression, vascular surgery, and other treatments

Objective: Although some meta-analyses have reported the efficacy of stem cells in the treatment of diabetic ulcers, their sample sizes are small and the outcome indicators are relatively single

Methods: All relevant studies in Cochrane, Embase, PubMed, Web of Science, China National Knowledge Infrastructure and Wanfang Database were systematically retrieved for meta-analysis

Results: A total of 14 studies with 683 participants were included in the meta-analysis

Figure 1a: Risk of bias plot

Figure 2 shows a forest plot of the effects of stem cell therapy on ulcer or wound healing rats

Figure 3 shows a forest map of the effect of stem cell therapy on amputation rates

Figure 4 a: Forest plot showing the effect of stem cell therapy on new blood vessels

Figures 5 a, b: Publication bias associated with ulcer or wound healing rate (10a) and amputation rate (10b).

Conclusion: The meta-analysis of the current study shows that stem cell therapy for diabetic foot is significantly superior to traditional methods and can improve the quality of life of

Original source:un Y, Zhao J, Zhang L, Li Z, Lei S,Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis update.