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For medical professionals' reading and reference only, April 27th, 19:00-20:30 China Invasive Mycosis Management Cloud Forum sincerely invites you to attend the conference! In recent years, with the increasing number of immunocompromised people, the incidence of invasive fungal diseases has increased year by year, and the distribution and drug resistance rates of pathogenic fungi have been changing
.
Especially in the current epidemic of COVID-19, the diagnosis and treatment of invasive fungal diseases still faces great challenges
.
In order to further explore the diagnosis and treatment plan of invasive fungal diseases, on April 27, 2022, from 19:00 to 20:30, Professor Shi Yi, Jinling Hospital Affiliated to Nanjing University School of Medicine, Professor Huang Haihui, Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University, Nanjing University Professor Su Xin from Jinling Hospital Affiliated to the School of Medicine gathered at the China Invasive Mycosis Management Cloud Forum to share the research progress and management practice of invasive candidiasis and cryptococcosis
.
Pay attention to the trend of Candida resistance, and rationally diagnose and treat pulmonary cryptococcosis! The group of sages has arrived, on the treatment of fungi
.
Recognize the QR code to watch the live broadcast, get exciting content, and participate in the discussion and interaction! Professor Shi Yi from Jinling Hospital, Nanjing University School of Medicine ▌Diagnosis and Treatment of Common Yeast Diseases in the Intensive Care Unit (ICU) Professor Shi Yi will conduct in-depth discussions with the experts present on the diagnosis and treatment of common yeast diseases in the ICU
.
With the improvement of China's medical level and the treatment rate of difficult and severe cases, the number of critically ill patients in the ICU has increased significantly [1]
.
According to a retrospective analysis of clinical data of 1005 ICU patients in Yixing People's Hospital from 2014 to 2017, Candida albicans is the most common deep fungal infection in ICU patients, and fluconazole is not effective in treating deep fungal infection in ICU patients.
, Amphotericin B and 5-fluorouracil have strong adverse reactions and limited clinical use [2]
.
Professor Shi Yi asked, how should we deal with the above situations? Professor Huang Haihui, Huashan Hospital Affiliated to Fudan University ▌How to formulate the diagnosis and treatment plan for invasive candidiasis (IC)? IC is an invasive infection caused by Candida in the human body, including bloodstream infection (also known as candidemia) and other deep infections (including intra-abdominal, bone and joint, brain, eye, heart, kidney, lung, liver and spleen) )
.
IC symptoms and signs are nonspecific, with a high fatality rate, and the distribution of its pathogenic bacteria has changed in recent years
.
Among various IC pathogenic bacteria, the proportion of non-Candida albicans, mainly Candida parapsilosis and Candida tropicalis, is increasing, and Candida glabrata shows lower sensitivity to antifungal drugs such as fluconazole and voriconazole.
The susceptibility of Candida tropicalis also showed a downward trend [3]
.
On the other hand, many studies have not found that five common pathogenic Candida are resistant to amphotericin B [3]
.
Professor Huang Haihui will introduce the diagnosis and differential diagnosis of IC in this forum, as well as the recommendations of major international guidelines for the clinical use of IC in different patient groups
.
Professor Su Xin from Jinling Hospital Affiliated to Nanjing University School of Medicine ▌Diagnosis and Treatment of Cryptococcosis Professor Su Xin will also explain the diagnosis and treatment of cryptococcosis in this forum
.
Cryptococcosis has now become a common clinical opportunistic infectious disease.
The most common infection site is the lungs.
In recent years, the incidence of pulmonary cryptococcosis has increased year by year.
If not diagnosed and treated in time, it may spread to the nervous system, especially the immune system.
Defective patients
.
According to a retrospective analysis of clinical data of 80 patients in Jinling Hospital from 2011 to 2016, the immune status of patients is related to the clinical manifestations of cryptococcosis [4]
.
Clinically, it is necessary to comprehensively evaluate patients and correctly understand pulmonary cryptococcosis [4]! Another study, also from Jinling Hospital, pointed out that new cases of cryptococcosis in Jiangsu Province were on the rise, and most of the patients had no immunodeficiency [5]
.
Faced with a variety of clinical manifestations and drug resistance, how to diagnose and treat the troublesome invasive fungal disease? China Invasive Fungal Disease Management Cloud Forum specially invites big coffee to solve the problems of diagnosis and treatment in an all-round way! References: [1] Yang Yan, Sun Jian, Zhang Qi, et al.
Clinical analysis of invasive fungal infection in 8 patients with autoimmune disease[J].
Chinese Journal of Medical Frontiers (Electronic Edition), 2011, 3(2):49-52.
[2] Shen Zhijuan, Zhou Ping.
Etiological characteristics and risk factors of deep fungal infection in ICU patients [J].
Chinese Journal of Frontiers in Medicine ( Electronic Edition), 2018, 10(05): 115-118.
[3] Yang Zhihui, Yu Jin, Li Ruoyu.
Epidemiological status of invasive candidiasis in China [J].
International Journal of Epidemiology, 2021, 48 (04):266-271.
[4]He Q, Ding Y, Zhou W, et al.
Clinical features of pulmonary cryptococcosis among patients with different levels of peripheral blood CD4+ T lymphocyte counts.
BMC Infect Dis.
2017;17(1 ):768.
Published 2017 Dec 13.
doi:10.
1186/s12879-017-2865-z.
[5]Wang, Yu et al.
“Clinical features of cryptococcosis in patients with different immune statuses: a multicenter study in Jiangsu Province-China .
” BMC infectious diseases vol.
21,1 1043.
8 Oct.
2021, doi:10.
1186/s12879-021-06752-x.
This article is only for providing scientific information to medical and health professionals and does not represent the platform’s position