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    Home > Medical News > Latest Medical News > Sei-LiFu Research Institute: Supplementing the anti-decay factor NAD plus, IS NMN the best?

    Sei-LiFu Research Institute: Supplementing the anti-decay factor NAD plus, IS NMN the best?

    • Last Update: 2020-07-31
    • Source: Internet
    • Author: User
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    Nad plus, full name niacinamide adenine dinucleotide, is a coenzyme in the human body and is said to be closely related to aging. Because scientists found that mice and animals such as the Siucry nematodes, where nad levels dropped as they age, similar findings were made in human trials. So they thought that raising THE NAD plus level might fight aging.
    , however, we often say what is missing to make up for what is not valid here in NAD plus. Studies have shown that direct supplementation of NAD plus does not relieve the symptoms of aging. Because direct supplement ingons of NAD cannot be absorbed and utilized by cells. As a result, the researchers could only look for an indirect way to raise the LEVEL of NAD plus. Therefore, the associated precursor NMN, precursor NR, reductive state NADH and other forms of supplements began to lead the way.
    these NAD-plus supplements have been called "anti-decay medicine" since their emergence, because many business circles, the effect is also good, by many people sought after. NR, NMN, NADH is the current supplement NAD plus three main ways, today we will comb the same can supplement NAD plus, how are they different?
    is a red NMN
    . NMN is an abbreviation for niacinamide mononucleotides, and has been used for 6 years. In 2013, an experiment by Paul F. Glenn Center for Biology of Aging, Harvard University, proved that NMN can extend the lifespan of mammals by more than 30 percent.
    Professor David Sinclair of Harvard Medical School and his team
    study found that when supplemented NMN enters the cell, and then consumes an ATP, the NAD-plus molecule is formed, which effectively increases the amount of NAD-plus in the body, helping humans repair DNA damage and delay aging.
    2016, a research team led by Japanese professor Ichiro Ichiro Ishii, at the University of Washington, published the latest research results of NMN in the American scientific journal Cell Metabolism, whose anti-decay effects were confirmed and began to be used in humans for three years.
    Professor Ichiro Ichiro, of the University of Washington,
    By 2018, Professor David Sinclair of Harvard Medical School will have once again demonstrated the anti-decay function of NMN by publishing the results of the NMN experiment in the top academic journal CELL. He said in an interview that he took 1000mg of NMN every day, and his family was eating it, feeling a lot younger. Then NMN by the major media and research institutions as "long-lived medicine" title. To that end, Professor David Sinclair was named "The 100 Most Influential People in the World" by Time magazine. From then on NMN became the darling of the anti-decay world.
    NMN this product is relatively easy to produce, so every month there are a large number of new brands into the market, but the quality is uneven, more representative brands including Gene Port, Riveto, Sai Lifu and so on.
    NMN fire, can not be separated from commercial speculation, we can see on the Internet every day a lot of big celebrities and NMN on the relationship, but there is no proof, most of Zhang Guan Li Dai. Take The Often-Hyped Buffett, who has invested heavily in NMN, without any strong evidence of the truth. And Li Ka-shing, Pan Shiyi, these business tycoons eat is not NMN at all. Although these are hype, but in marketing is undoubtedly very useful, the future may also appear a lot of "Buffetts", which makes the author inexplicably some worry, this is a good thing, will not be this kind of fish and dragon mixed publicity to make everyone do not know what to believe?
    although NMN is very hot at present, but because of a variety of products without security testing have poured into the market, the industry began to worry about its security issues (Tencent more true column has sent a more true evaluation of NMN), but so far has not found strong evidence that there is some kind of risk, so some responsible businesses in order to protect its safety and do something.
    Gene Port, Riveto, Sei-Fu three representative NMN products, in addition to can not find Riveto's proof of safety, Gene Port and Sai Lifu are available in official channels.
    such as Gene Harbor showed the United States FDA standard GRAS certification, because the United States FDA for NMN such products to take the after-the-fact filing system, and will not be in the early stage of certification, and this certificate is noted as "self-certification", so this certificate is often criticized, but can not deny that the business wants to prove the safety of the product of the first mind.
    self-certification is the most liberal of the three forms of GRAS certification, in the form of a panel of experts to defend themselves if someone questions it.
    A screenshot of the jinggang JD.com overseas flagship store
    another Sai Lifu showed a long-term safety test conducted by the Zhejiang Academy of Medical Sciences in 2016, which was tested for 8 months from cells, genes and other levels (according to industry insiders, 8 months of safety testing is a very high standard). The test report shows that
    2017 to get the report, when NMN has not yet entered China, through investigation to understand the earliest time of Sai Lifu NMN China market is August 2019, during which the manufacturers are not because of safety concerns and did not launch us early, but in the current market view of the report's gold content is still relatively high. Screenshot of the flagship store of
    SaiLi Fujingdong Overseas
    . NMN has been praised as the best way to supplement NAD plus because it is a direct precursor of NAD plus, but because NMN needs the help of enzyme NMNAT in the conversion process and needs to consume ATP, the conversion rate is limited, and scientists are currently working on ways to improve conversion efficiency or to develop more efficient analogies.
    celebrities add NR
    . NR is an abbreviated for niacinamide ribose, it is the precursor of NMN, into the body needs to be converted into NMN and then converted to NAD, the mechanism of action is basically consistent with NMN, but because of the need for multiple conversions, the conversion efficiency is lower than NMN. NR into the human body after the need for NPK1 to 2 phosphorylation into NMN, and the mitochondrial body without NPK1 and NPK2 enzymes to turn NR into NMN. More crucially, most of nR is not converted into NMN, but digested as niacinamide (NAM). Oral NR is mostly digested into NAM in the body, still can not change the remedy synthesis pathway speed limit enzyme NAMPT limit, so the ability to supplement NAD plus is limited.
    has been studied as early as 2004 to show that NR can reduce age-related functional decline in various mouse models, and it has been used for 15 years. But in fact, the real human take time of NR is from 2012, about 7 years of history, has been published human safety experiments also have four. Although before the NMN was applied but not as famous as NMN, probably because of the limitations of absorption rate. The iconic brands are Tru Niagen of ChromaDex and Basis of Elysium.
    really made NR famous for two celebrity events:
    in 2017, Hong Kong's richest man Li Ka-shing invested $25 million in ChromaDex's Tru Niagen, in Hong Kong called "Le Gasin", and now the online concept of multi-stealing it is called NMN, in fact, it is not. This "celebrity effect" bar, really let nR fire, but the results do not seem very optimistic, there are media reports that ChromaDex in the second quarter of 2019 net loss of $775.5 million, it is clear that the product is not popular.
    another is that earlier this year, PAN Shiyi, chairman of SOHO China, posted a tweet, "I never believe in health care products." But a month ago, a professor at the Massachusetts Institute of Technology recommended a 'long-lived son-in-law' from their school that hasn't gone on the market. I asked him how he felt after eating. 'After eating, the nails grew fast, ' he said. I ate for nearly a month, had little reaction and found my fingernails growing fast. "The map is a health product produced by an American company called Elysium, which is rumored to be NMN, but also NR.
    the addition of two big men to make NR shine, attracted attention.
    but NR in addition to low conversion rate, there is a fatal weakness is not able to biosynthesis, only chemical synthesis, the production process needs to add chlorine elements to ensure its stability, so that the synthetic NR is no longer the natural NR in the human body, so there may be unknown security risks. There have been reports of oral NR with side effects such as vasculatording and redness of the skin. Probably congenitally deficient, so NR as a way to supplement NAD plus has been tepid.
    delicate and efficient NADH
    . NADH is also the initials of the archetypal nicotinamide adenine dinucleotide, which is the reductive state of NAD plus. The international authoritative medical health information platform Of the United States WebMD website introduces NADH is the niacinamide adenine dinucleotide (NAD plus) plus hydrogen (H). NADH can quickly break down into NAD plus after entering the body, where, unlike NMN and NR, NADH is a decomposition reaction, much easier, and NMN and NR to synthesize NAD plus is more difficult. Because NADH is very easy to break down, the efficiency of converting to NAD plus is the highest in the NAD-plus family.
    applied research on NADH has been in the field since 1987, has been taking human body for more than 30 years, according to the FDA Adverse Event Reporting System (FDA Adverse Event Reporting System) data, as well as many years of user feedback, there have been no side effects reported, has been published human safety experiments also have more than 20, but why the market NR, NMN have been widely publicized, a variety of brands have not been involved in the emergence of NADH? In fact, Cheng also Xiao He defeat, the root cause is still the stability of NADH is difficult to solve. In foreign countries, NADH has been the first to be used in the treatment of a variety of diseases, but because it is very unstable, easy to degrade, can only be used immediately, but also directly through intravenous use, this method is difficult to promote, difficult to produce applications, so scientists are committed to tackling the problem.
    (FDA's description of NADH instability)
    the current market of NADH products are mostly under-tongue tablets, long-term stability and effectiveness is questionable, under the tongue of this method of taking tablets is also controversial whether there is a safety risk. It is understood that the first to overcome the stability problem, really can achieve long-term stability is also mentioned above, it uses a special process called Turn-A delivery system, to ensure the long-term stability of NADH and efficient absorption. It is worth mentioning that SeyleeFu NADH has been granted NPN certification in Canada (the Health Department of Canada's official website can access the relevant information).
    mention edited this NPN certification is to say that the national health care regulatory system in fact, the standard is uneven, but also a IQ tax "heavy disaster area." According to the existing national regulations on health care products, Canada is one of the world's most stringent regulatory health care products, a product to be marketed, Health Canada will be the product formulation of a strict review, to ensure that the ingredients in the statutory natural health product catalog, the use of raw materials in the human safety range, and the use of raw materials will not interact with human security risks, after up to a year or so of approval time to grant NPN certificate, before going on the market. In this regard, the U.S. FDA is only after-the-fact filing system, and Japan is polarized, only for specific health food strict regulation, most products can be easily marketed and sold, both countries are far less than Canada, so can obtain NPN certificate, security content is still very high.
    need to emphasize that in the existing domestic and foreign markets, including NMN products, can get this NPN certificate is very few. In fact, NMN can not obtain NPN certification, because it is not included in Canada's natural health products statutory raw materials catalog range, it can be seen that the safety of NMN to obtain official recognition is still a long way to go.
    are talking about anti-aging, but really more than which reliable, certainly around the mechanism of aging research. The latest ageing biology textbook, "Jerry and Cell Biology of Ageing", in 2019, summarizes decades of aging research, attributing the mechanism of aging to two major problems: free radical oxidation damage and declining NAD-plus levels. NADH is able to efficiently decompose into NAD plus and hydrogen when it enters the body, which raises the level of NAD plus, and hydrogen is the ideal substance for efficiently removing free radicals, as if NADH solves both the most core problems of aging. Thus, NADH will occupy an important position in the future anti-decay market.
    long life is not old this desire, since ancient times has been haunting people's hearts. Male talent is slightly like Qin Huanghanwu, also for this matter paid a lot of "IQ tax." Some people also suspect that NAD plus is the delusion of the pursuit of life-extending anti-decayer another IQ tax, but after analysis found that the NAD plus family, although the advantages and disadvantages are clear, but still a material. So we should face new things with a rigorous and open attitude, neither blindly follow the trend, nor blindly deny,
    if the early developers of vaccines and antibiotics are also tied to, many people may not survive the year. The medical developments of the past two centuries have taught us that humanity has the ability to defeat the diseases that have caused us suffering, and if we focus on that, perhaps we can really beat the fate of aging.
    reference
    . 1. Mouchiroud L, Houtkooper R H, Moullan N, et al. The NAD plus/sirtuin pathway modulates longevity through activation of the mitochondrial UPR and FOXO signaling . Cell, 2013, 154 (2): 430-441.
    2. Z.
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