Seize the metabolic weakness of cancer! Real-time metabolic tracking and fat-free diet Tumor diagnosis and treatment effect is good.

The study was carried out by the team of the iKnife Smart Knife inventor, Zoltan Takats of Imperial College London, and George Poulogiannis, and the findings were published in the journal Cellfive years ago, Professor Zolta Takats invented the smart scalpel iKnife, which uses charge to burn cancerous tissue, extractinformation from the gas emitted by tissue combustion, and feed it back to surgeons, helping doctors accurately remove cancerous tissue, reducing damage to cancerous tissue and reducing the risk of postoperative tumor regenerationThe combination of iKnife with rapid evaporation ionization mass spectrometry (REIMS) enables instantaneous chemical analysis of aerosols produced during tissue burningSpecifically, in the latest study, scientists studied cancer cells and patient-derived tumors in the lab through iKnife to look for "metabolic fingerprints" and later discovered a molecule called PI3K, which is critical to the growth and survival of cancer cells and plays a key role in triggering the release of peanut tetraoleic acid, a key omega-6 fatThe researchers found that the mutation form of PI3K (PIK3CA) drives multiple signaling pathways, which involve the activation of another key molecule, cPLA2, which releases peanut tetraoleic acid, which in turn contributes to uncontrolled growth and spread of cancerteam later showed in mouse studies that a new drug called cPLA2 inhibitors , which is used in clinical trials to treat various inflammatory diseases , could be used to treat fat-dependent cancersBut these drugs are only effective if combined with dietary changes to limit fat intakeBecause, when mice were treated with a drug that inhibited cPLA2 and fed a plant-based fat-free diet at the same time, tumors with the mutant PI3K stopped growing and spreadingHowever, cPLA2 inhibitors were ineffective when mice were fed a "western" diet rich in omega-6 fatty acidsThe researchers concluded that targeting cPLA2 is only effective when peanut tetraoleic acid or other fats without a dietary source contribute to cancerIn other words, for these drugs to be effective, a fat-free plant diet must be adoptedOf course, they stress that these findings apply only to the use of these experimental cPLA2 inhibitors, not that the presence of fat interferes with any existing anticancer drugs, or that fat restrictions in the diet prevent tumorgrowth"We've known for a long time that cancer has genetic weaknesses that can be treated, but our research shows that cancer salsos with specific metabolic weaknesses"We found that tumors often rely heavily on specific fats and their products to promote their growth and spread, and the ability to stop them from processing them may be an effective treatment," says DrGeorge PoulogiannisProfessor Paul Workman, director of the Institute of Cancer Research in London, said: "This is an exciting and important study that suggests that cancer can be understood and treated by looking at so-called metabolic fingerprint mapsThe new findings identify specific metabolic weaknesses in cancer cells that can be used in combination with a fat-free diet through innovative drugs; In summary, this study suggests that preventing a particular cancer subtype from releasing a key omega-6 fat called peanut tetraoleic acid may be an effective treatment, but only if the source of the fat in the diet is removed In addition, analyzing metabolic fingerprints of cancer is a key tool for understanding, diagnosing and treating the disease In the future, it may be possible to analyze the metabolic fingerprints of cancer when patients use iKnife's operating table, and combine them with medications and dietary therapies Related: "Cancer's reliance on fat betabswith new 'drugs and diet' treatment s2" Cell: New Model smh.com.au: real-time metabolic tracking and dietary intervention.