Selection of Analysis Conditions for Determination of 5 Benzimidazole Drug Residues in Milk and Milk Powder——Optimization of Extraction Method

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(1) Optimization of extraction method

1) Selection of extraction solution

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Table 17-5 The influence of different extraction solutions on recovery

It can be seen from the results that when methanol, acetone, and ethyl acetate are used as the extractant, the recovery rate of each component is relatively low, and when acetonitrile is used as the extractant, the recovery rate of the analyte is relatively ideal

2) Selection of the amount of extract

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Table 17-6 The influence of the amount of extract on the recovery rate (%)

It can be seen from the results that the recovery rate of the five benzimidazole drugs is low when extracted with 10 mL of acetonitrile.

3) Selection of the amount of n-propanol

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Table 17-7 The influence of the amount of n-propanol on the recovery rate

It can be seen from the results that adding n-propanol before evaporating and removing the organic solvent shortens the concentration time and significantly reduces the concentration loss.

Related Links: Procedures for determination of 5 kinds of benzimidazole drug residues in milk and milk powder