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Gastric cancer disease research and disease model
Data from the National Cancer Center of China show that in 2019, the incidence and mortality of gastric cancer in China are ranked second and third among all malignant tumors, far higher than the world average
Gastric cancer is a carcinoma derived from epithelial cells of the gastric mucosa, and the most common pathological type is adenocarcinoma
Gastric cancer is divided into adenocarcinoma, signet ring cell carcinoma, adenosquamous carcinoma, medullary carcinoma, and undifferentiated cell carcinoma according to the pathological type
The treatment of advanced gastric cancer still has a long way to go.
Gastric cancer has its own unique laws and strong heterogeneity.
Cell lines, animal models, and patient-derived tumor xenograft models all lack the characteristics that characterize the occurrence and development of gastric cancer, which limits the research on the pathogenesis of gastric cancer and the development of therapeutic drugs.
Signet ring cell gastric cancer (SRCC)
The incidence of signet ring cell carcinoma accounts for about 9.
Gastric signet ring cell carcinoma (gastric signet ring cell carcinoma), also known as gastric mucinous cell carcinoma, is a special pathological type of gastric cancer.
Gastric cancer organoid disease model
.
Validation data display of gastric cancer organoid disease model (PDO model and PDOX model)
Gastric cancer is a carcinoma derived from epithelial cells of the gastric mucosa, and the most common pathological type is adenocarcinoma
.
Data from the National Cancer Center of China show that in 2019, the incidence and mortality of gastric cancer in China are ranked second and third among all malignant tumors, far higher than the world average
Gastric cancer is a carcinoma derived from epithelial cells of the gastric mucosa, and the most common pathological type is adenocarcinoma
Gastric cancer is divided into adenocarcinoma, signet ring cell carcinoma, adenosquamous carcinoma, medullary carcinoma, and undifferentiated cell carcinoma according to the pathological type
The treatment of advanced gastric cancer still has a long way to go.
Gastric cancer has its own unique laws and strong heterogeneity.
Cell lines, animal models, and patient-derived tumor xenograft models all lack the characteristics that characterize the occurrence and development of gastric cancer, which limits the research on the pathogenesis of gastric cancer and the development of therapeutic drugs.
Signet ring cell gastric cancer (SRCC)
Gastric signet ring cell carcinoma (gastric signet ring cell carcinoma), also known as gastric mucinous cell carcinoma, is a special pathological type of gastric cancer.
The cancer cells are filled with a large amount of mucus, and the nucleus is tilted to one side, which looks like a ring.
Name
.
The incidence of signet ring cell carcinoma accounts for about 9.
Gastric signet ring cell carcinoma (gastric signet ring cell carcinoma), also known as gastric mucinous cell carcinoma, is a special pathological type of gastric cancer.
Gastric cancer organoid disease model
We have successfully constructed a new batch of gastric cancer organoid models (PDO) and gastric cancer PDOX mouse models, and verified the models as follows:
We have successfully constructed a new batch of gastric cancer organoid models (PDO) and gastric cancer PDOX mouse models, and verified the models as follows:Histopathological structure of the model (HE&IHC)
Histopathological structure of the model (HE&IHC)Model's continuous multi-generation stable amplification and passage performance
Model's continuous multi-generation stable amplification and passage performanceConstruction of tumorigenesis model of some gastric cancer organoids in vivo, PDOX model
Construction of tumorigenesis model of some gastric cancer organoids in vivo, PDOX modelOncoCode Panel (673 gene) NGS test
OncoCode Panel (673 gene) NGS testSome organoid models of gastric cancer have self-matched immune cells
Some organoid models of gastric cancer have self-matched immune cellsThese gastric cancer organoid models can be used as tools for gastric cancer biomarker discovery and identification, gastric cancer drug development and gastric cancer clinical medicine translational research, and provide relevant research and development technical services for new drug research and development companies and major scientific research institutes
.
.
Validation data display of gastric cancer organoid disease model (PDO model and PDOX model)
Figure 3: Typical brightfield photos of gastric cancer organoid models (KO-99213 and KO-24540)
Figure 4: Typical HE stained photos of gastric cancer organoid models (KO-42212 and KO-41277)
Figure 5: Cell staining photos of signet ring cell gastric carcinoma (SRCC) organoid models (KO-47650 and KO-97876)
Figure 6: Data of rapid tumor formation in KO-66744 PDOX mice with organoids of gastric cancer
Figure 7: Photo of tumor formation in KO-66744 PDOX mice with organoids of gastric cancer
Figure 8: Typical HE staining photos of PDOX mouse model of gastric cancer organoids (KO-99213 and KO41277)
Selected Product List of Gastric Cancer Organoid Models Gastric Cancer Organoid Construction and Culture Kit Product List Leave a message here
