echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > Selective estrogen receptor degrader (SERD) amcenestrant in breast cancer fails to meet primary endpoint

    Selective estrogen receptor degrader (SERD) amcenestrant in breast cancer fails to meet primary endpoint

    • Last Update: 2022-04-22
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Estrogen receptor (ER) plays an important role in gene transcription and proliferation in ER-positive breast cancer
    .


    Selective regulation of the ER has been a therapeutic target for this specific type of breast cancer for more than 30 years


    breast cancer

    Estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer is the most common type of breast cancer, accounting for 65% of breast cancer cases in women under the age of 50 and breast cancer cases in women 50 and older 75%
    of .


    Estrogen binds to the ER and stimulates receptor-regulated transcription, which in turn promotes tumor cell growth and proliferation


    Sanofi today announced that a Phase II study of its experimental selective estrogen receptor degrader (SERD) amcenestrant failed to meet its primary endpoint of improving progression-free survival (PFS) in certain breast cancer patients
    .


    "Despite the disappointing results, we will continue to study the efficacy of amcenestrant in patients with early breast cancer with different tumor characteristics," said John Reed, head of research and development at Sanofi


    Sanofi today announced that a Phase II study of its experimental selective estrogen receptor degrader (SERD) amcenestrant failed to meet its primary endpoint of improving progression-free survival (PFS) in certain breast cancer patients


     

    Original source:

    Original source:

    https://firstwordpharma.


    https://firstwordpharma.
    com/story/5524831 https://firstwordpharma.
    com/story/5524831 Leave a comment here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.