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Semin Cancer Biol: A new direction for precise cancer treatment: gut microbes

 Last Update: 2021-04-16
 Source: Internet
 Author: User

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The microflora affects human health and the development of many diseases, including cancer.

Immunity Prevention Semin Cancer Biol Semin Cancer Biol recently published a review that discussed the role of microflora in tumorigenesis and cancer treatment, focusing on the use of microflora to fight cancer.

The microflora, especially the intestinal microflora, shapes the host's immune system by regulating local and systemic immune responses.

Microorganisms trigger local immune responses by interacting with immune cells that express pattern recognition receptors (PRRs) (eg, Toll-like receptors [TLRs]).

Microorganisms promote or inhibit tumors in a tissue-specific manner.

Tumor immunity

The role of chemotherapeutic drugs is closely related to the host's immune response.

The use of microorganisms, their components, or both, may help identify biomarkers and therapeutic targets that may contribute to the development of cancer immunotherapy.

Manipulating microbial networks is a promising strategy for the treatment of cancer.

antibiotic

There is increasing evidence that the gut microflora plays an important role in influencing tumorigenesis and cancer cell response to therapeutic drugs.

Microbial manipulation can be used as an adjunct to traditional cancer treatment, or as an independent treatment after standard treatment fails.

Inamura K.

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