, a new biomarker, could help researchers develop new therapies that precisely target and kill cancer cells before they spread, says researcher Pamela Pollock. To specifically detect genetic mutations that cause malignant endometrial and uterine cancer, this biomarker is based on mutations in the FGFR2 gene (Fibroblast Growth Factor Receptor 2, fibroblast growth factor receptor), which is expressed in 40 percent of the 386 patient tumor samples studied in this study.
FGFR2 gene mutations are directly related to the shortening of survival and disease-free survival in a significant number of female patients, and in earlier studies, researchers found that FGFR2 mutations were able to turn on protein expression all the time, while recent studies have found that researchers have found a way to Turning on a new method of expression of FGFR2, the researchers believe that a mutation called FGFR2c may be used to adjust the prognosis of endometrial cancer patients and as a predictive biomarker to indicate whether tumors are resistant or sensitive to FGFR inhibitors.
image Source: medicalxpress.com BJBMS: Identification of independent biomarkers doi: 10.17305/bjbms.202 indicating the prognosm of stomach cancer 0.4620 Although scientists have made several advances in the diagnosis and treatment of stomach cancer in recent years, it is still an important public health issue, so in addition to the classic method, scientists need new biom molecules to help predict the prognosis of stomach cancer and develop new targeted therapies.
, scientists from Turkey's Feirat University identified a new independent prognosm index for stomach cancer in a study published in the international journal Bosnian Journal of Basic Medical Sciences.
researchers say the P2X7 complex is a special molecule that is thought to play a number of important roles in inflammatory events and cancer progress, and that the subject is located on the cell membrane and increases its level in many types of cancer.
Previously, researchers found that P2X7 subjects may be biomarkers of adverse prognostics of a variety of malignant tumors, such as pancreatic, colorectal and kidney cancers, but after recent studies of cancer cell line, scientists have found that P2X7-like antagonists are effective in slowing tumor growth, but no detailed clinical studies have been conducted to investigate the effects of P2X7 on the prognostic effects of P2X7 on the treatment of stomach cancer patients.
: Scientists have successfully identified 1,178 biomarkers or are expected to help predict disease progression in prostate cancer patients doi:10.1038/s41591-019-0579-z In a study published in the international journal Nature Medicine, scientists from the University of California and other institutions identified 1,178 biomarkers in the male genome that could help effectively predict the growth of prostate cancer in the male body, suggesting that clues to the progression of prostate cancer in men may be in their genetic DNA. In the
article, the researchers focused on a biological process called DNA methylation, in which DNA methylated cells turn genes on or off to promote natural processes of normal physiological changes, and DNA methylation begins when special chemical groups (methyl groups) are added to key parts of DNA that control cell function, such as protein production, which often blocks DNA methylation when it forms to help cancer cells grow and spread by turning cell function on and off.
: Scientists have discovered a new biomarker for type 1 diabetes, doi:10.1007/s00125-019-04980-0 Recently, researchers from the Turku Center for Biological Sciences in Finland found a new biomarker in the blood that indicates type 1 diabetes.
may help to understand the early pathogenesis of the disease.
the highest incidence of type 1 diabetes among children under 15 years of age.
, in many developed countries, the prevalence of the disease among children is increasing.
using the latest metabolomic methods, researchers at the Turku Center for Biological Sciences found changes in metabolites in the blood prior to the emergence of islet autoantibodies.
findings may be important for finding early markers of type 1 diabetes and understanding the pathogenesis of the disease.
in current clinical practice, islet autoantibodies are the first detectable pathogenesis.
, however, it may be too late for autoantibodies to be detected to prevent the occurrence and development of diabetes.
: MicroRNA methylation may act as a powerful biomarker for cancer: 10.1038/s41467-019-11826-1 Scientists from Osaka University have found in a study published in the international journal Nature Communications A new method to distinguish between early pancreatic cancer patients and healthy people may help develop new methods for early diagnosis of pancreatic cancer; molecular levels associated with genetic function, such as microRNA, are key indicators of cancer-related abnormal activity, but researchers aren't sure how different molecules are altered in cancer cells, and now researchers have developed a new way to effectively distinguish between cancer tissue and non-cancerous tissue.
researchers say the rate of methylation in microRNA can effectively distinguish cancer patients from healthy individuals; microRNAs can exhibit abnormal expressions in cancer tissue and are stable in body fluids, so they can act as useful biomarkers to indicate cancer occurrence; although researchers can measure RNA expression levels microRNAs, however, lack the sensitivity and accuracy of technology, especially since microRNAs are based on the assumption that targets can be identified and regulated whether they are methylated or not, their role actually changes with the different methylation states, which researchers want to solve through research.
"10" JCI Insights: New biomarkers can diagnose severe kidney allergic reactions doi:1 0.1172/jci.insight.127456 A recent study by medical researchers at Johns Hopkins University identified two protein biomarkers in urine that could one day be used to better diagnose acute interstitrin nephritis (AIN).
AIN is an undiagnosed but treatable kidney disease that can impair kidney function in the short term.
, if left unalted, can lead to permanent damage or kidney failure.
the findings were published in the journal JCI Insights.
acute interstitrinal nephritis is a condition characterized by inflammation and swelling of the kidney tubes, the kidneys