In the study, researchers from institutions such as the University of Nevada divided the mice into four groups and tested them separately.
Each group of mice was treated with antibiotics, but at the same time they received a different diet: the first group ate a high-fat, high-protein diet, the second group had a high-fat, low-protein diet, the third group had a high-carbohydrate diet, and the fourth group had a standard laboratory diet for laboratory mice.
photo Source: Xingjian Xu and Edwin Pozharski: Scientists hope to develop a new drug treatment for Thyrobacter difficile infection doi:10.1073/pnas.19194901117, a recent publication in the international journal Proceedings of the National Academy of Sciences Scientists from institutions such as the City University of New York have studied or are expected to help develop new drugs to treat Clostridium difficile infections, which can cause diarrhea, nausea, internal bleeding and potential deaths, pose a serious threat to public health, infecting about 500,000 people and killing 15,000 people in the United States each year, according to a study in Science.
The overuse of antibiotics is increasingly putting patients in medical facilities, putting them at risk of contracting Ocythrobacteria, which also makes certain strains more difficult to treat; in this study, researchers found that a toxin released by Thoreau could help them develop new drugs to block the function of the toxin, while also effectively inhibiting bacteria from entering human cells to cause infections.
Acta Pharma Sinica: How does Thyrobactertoxin A get into intestinal cells? doi:10.1038/s41401-019-0242-8 Thyrobacteria infection has become a major and sometimes fatal cause of diarrhoeal diseases and a growing problem in daily life.
diseases from C. diff are caused by toxins produced by bacteria that damage the inner walls of the intestine.
a recent study published in the international journal Acta Pharmacologica Sinica, the authors revealed how C. diff's two main toxins, A and B, enter the intestine cells, providing preliminary clues to the development of antibiotic-free treatments.
2016, Dong and his colleagues revealed the entrance to toxin B.
using CRISPR/Cas9 gene editing techniques, they screened all genes in human cells because of their potential role in toxin binding and entry into cells.
when they mutate a gene called Frizzled, the toxins fail to enter the cells and the intestinal tissue becomes less sensitive.
PLoS Pathog: How does Thyrobacteria dominate the gut with the special compounds it produces? doi:10.1371/journal.journal.ppat.1007191 Thyrobacteria is responsible for most antibiotic-related diarrhoeal outbreaks around the world, according to a study published in the international journal PLoS Pathogens. Scientists at the School of Tropical Medicine have found that Thyrobacteria can produce a special compound called p-cresol, which helps Thyrobacteria gain a competitive advantage in the patient's intestines, which invisibly affects the function of the naturally protected bacterium in the patient's gut.
The use of antibiotics interferes with the body's naturally protected gut bacterium, making patients susceptible to Tracyrobacteria infections, which can lead to potentially fatal diseases and complications; But one of the problems is that Thyrobacteria is one of 18 known intestinal bacteriums in the gut that produce compounds that inhibit the growth of a wide range of microbiomes in the gut, but only affect Ocythrobacteria at high concentrations.
9 Science: New study promises to beat the deadly Thyrobacteria gastrointestinal infection doi:10.1126/science.aar1999 In a new study, researchers from the University of California, Irvine and Harvard Medical School found how TcdB identifies human G-protein-coupled infection Flizzled protein (FZD), which is used to invade intestinal cells and cause fatal gastrointestinal infections.
could pave the way for the development of new antitoxins against Thyrobacteria and show potential for the development of new anti-cancer drugs.
study was published in the journal Science.
TcdB targets colonal cortectal cells and binds to FZD binds to FZD in a difficult Thyrobacteria infection.
the researchers found that during this binding process, the toxin locks certain lipid molecules in FZD, which blocks the transmission of key Wnt signals that regulate colon stem cell renewal and colon skin differentiation.
, a researcher, says the toxin is really very witty.
it uses an important lipid used by FZD receptors to perform its own function to improve its binding affinity and specificity to FZD receptors.
, however, the need for this lipid also exposes a weakness of TcdB, which could be used to develop antitoxins that block the identification of the toxin-subject.
10 Nature: Heavy! Increased frequency and severity of the Clostridium difficile epidemic in dietary algae increases the toxicity of Clostridium difficile: 10.1038/nature25178 is associated with the widespread use of the food additive seaweed sugar.
In a new study, researchers from research institutions such as Baylor College of Medicine in the United States found that seaweed sugar increased the toxicity of the endemic Thyrobacteria spectrum, which dominates infection in patients, in laboratory tests and animal models, the study was published in the journal Nature.