Several countries are advancing the clinical transformation of stem cells to treat osteoarthritis.

In recent years, the clinical transformation of stem cells to treat osteoarthritis has been making progress.
, China has 3 new stem cell drug for osteoarthritis clinical trial application for implied permission.
stem cell treatment osteoarthritis in China is developing rapidly towards clinical conversion application.
, the clinical application of stem cells to treat osteoarthritis is also well received.
recently, Health Canada approved a stem cell research project for osteoarthritis.
the project is aimed at patients with osteoarthritis between the ages of 19 and 79, stem cells are sourced from body fat or bone marrow, in addition to the patient's blood rich plate plate plate plasma (PRP).
Subjects were randomly divided into three groups, the first group of treatments: platelet-rich plasma combined with granulated adipose tissue, the second group of treatments: platelet-rich plasma combined with bone marrow puncture fluid, and the third group of treatments: particulate adipose tissue and bone marrow puncture fluid.
the main purpose of the study is to determine which biomass tissue is best clinically effective.
the entire research project will recruit 255 people, with an estimated completion date of December 2023, according to the website of the website.
, the U.S. has made new progress in recent days.
a FDA-approved clinical trial of stem cells for osteoarthritis has been officially completed, with 38 patients participating in a clinical trial to treat one knee with their own stem cells.
, the clinical application of stem cells to treat osteoarthritis is very broad, and many countries are jointly promoting clinical transformation.
stem cell treatment for osteoarthritis taken seriously? Osteoarthritis to joint cartilage degeneration damage, cartilage sclerosis, membrane hyperplising as the main pathological characteristics, there is a certain degree of disability, clinical symptoms are: pain, swelling, cartilage damage, morning stiffness, walking inconvenience, etc. , late onset, joint deformation, patients gradually limited activity, loss of joint function leading to disability.
is very difficult for the human body to repair damage to certain tissues, and cartilage is such a limited repair capacity of tissue.
cartilage does not have its own blood supply, so the cartilage area metabolism is slow, oxygen, growth factors, nutrients and other substances to help repair the damage is difficult to transport to cartilage.
repair time is often prolonged during cartilage injuries, and the damaged area may be further expanded during the repair process.
Three explains why even strong young people feel discomfort or pain in the damaged areas from time to time after the damage to the limbs and hands heals, and sometimes even affects joint movement for life.
At present, traditional treatment methods include painkillers, hormones, external applications, physiotherapy and surgery, as far as possible to slow the progress of the disease, while alleviating the patient's pain, but not to achieve the goal of cure, there are many limitations and shortcomings, clinically urgent need to develop a new drug treatment osteoarthritis.
recent years, stem cell therapy has attracted attention in the field of orthopaedics.
based on tissue repair, immunomodulation and antioxidant effects, stem cell therapy has made important progress in the field of osteoarthritis disease.
stem cells have the potential for self-renewal and multi-way differentiation, can differentiate a variety of cells to replace damaged cells in the body, but also secrete cytokines and other substances, stem cells this characteristic helps to reduce arthritis and promote bone, cartilage tissue regeneration, thereby repairing joint tissue.
stem cell drug in osteoarthritis treatment has been approved internationally listed stem cell products.
2009, the European-approved stem cell drug Chondrocelect was launched for treatment of cartilage defects in the knee.
In 2012, South Korea approved the interstitial stem cell drug Cartistem for the treatment of degenerative arthritis and knee cartilage injuries, and in 2016, the United States approved the listing of the stem cell drug Maci for the treatment of knee cartilage injuries.
At present, China is actively promoting the research and application of stem cell drugs in the treatment of osteoarthritis, a total of 3 new stem cell drugs for osteoarthritis obtained clinical approval, namely, human umbilical cord-filled stem cell injection, auto-human-sourced fat-filled progenitor cell injection and heterogenous human-sourced fat-filled progenitor cell injection.
In 2019, "The Role and Mechanism of Joint Tissue-Specific Stem Cells in Osteoarthritis" received 5.45 million scientific research grants from China's Stem Cell and Transformation Research Project, with a duration of 5 years, indicating that China has affirmed the clinical application value of stem cells in osteoarthritis.
2018, China will re-accept the declaration of new stem cell drugs.
10 clinical default permits have been obtained so far, 4 of which are related to arthritis, indicating that stem cell therapy has a better effect in arthritis.
Stem cell drug clinical study in osteoarthritis treatment 2019 Taiwan scientists transplanted human umbilical cord-filled stem cells to repair animal osteoarthritis, the results showed that compared with the control group, the bone joint treated with interstate-filled stem cells showed significant histological improvement in cartilage regeneration, which was highly evaluated by the International Society of Cartilage Repair Organizations.
2018 U.S. scientists published in Stem Cell Research and Therapy the source of interstitial-filled stem cells for the treatment of osteoarthritis.
clinical studies have shown that exosomes secreted by interstitial stem cells isolated by intraartal injection of bone marrow can protect joint cartilage infariance and delay the development of osteoarthritis.
has good tolerance and promising prospects for this cell-based treatment.
addition, Chinese researchers in China Zhinet, China Biomedical Database, Wanfang Database, Pub Med, Embase on the "interstate stem cell transplantation treatment of knee osteoarthritis clinical randomized controlled trials."
14 related documents, involving 710 patients with knee osteoarthritis, for meta-analysis.
results show that interstate stem cell transplantation can significantly improve knee pain and dysfunction in patients with osteoarthritis, and is expected to become a new method of treatment for osteoarthritis in the knee.
prospect of using stem cells to treat osteoarthritis has become a hot research topic, clinical trials at home and abroad have initially proved the safety and effectiveness of stem cell treatment of osteoarthritis, is expected to become the next generation of osteoarthritis treatment of new therapies.
with the development of regenerative medicine technology, stem cell therapy will become a blessing for osteoarthritis patients! References: Wu KC, Chang YH, Liu HW, Ding DC: Casting human umbilical cordsenchymal stem cells and hyaluronate hydrogel hydro repairs cartilage of osteoarthritis in the minipig model. Ci Ji Yi Xue Za Zhi 2019, 31 (1): 11-19. Damia E, Chicharro D, Lopez S, Cuervo B, Rubio M, Sopena JJ, Vilar JM, Carrillo JM: Adipose-Derived Mesenchymal Stem Cells: Are a Good Therapeutic Strategy for Osteoarthritis? Int J Mol Sci 2018, 19 (7). Freitag J, Bates D, Boyd R, Shah K, Barnard A, Huguenin L, Tenen A: Mesenchymal stem cellrapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review. BMC Musculoskelet Disord 2016, 17:230.