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The asymmetric reduction of carbonyl compounds and imine substrates is one of the most important strategies for the synthesis of chiral alcohols and chiral amines
.
Among the current asymmetric reduction methods, organic-catalyzed asymmetric hydrosilation reduction has received widespread attention in recent years because of its low price, stable chemical properties, and easy control in experimental operations, which is conducive to industrialization
In recent years, a series of chiral organic small molecule catalysts have been synthesized and reported, and they have been successfully used in asymmetric hydrosilation reduction reactions
.
This article mainly summarizes and categorizes from the perspective of catalysts, including four major categories of catalysts: chiral Lewis bases, chiral Lewis acids, chiral Bronsted acids, and chiral quaternary ammonium salts (Figure 1)
The article focuses on the activation model of Si-H bond and chiral control mechanism of various types of organic small molecule catalysts in hydrosilation reduction, which can provide a valuable reference for the development of asymmetric reduction and inspire chemists Develop a more economical and efficient catalytic system to achieve asymmetric catalytic reduction of more types of substrates
.
Figure 1.
Four catalytic types of asymmetric organo-catalyzed hydrosilation reduction
Finally, the author looks forward to the future development trend of asymmetric organo-catalyzed hydrosilation reduction, especially the application potential of chiral ion pair catalysis in asymmetric hydrosilation reduction reactions
.
This article will provide a useful reference for the development of a more economical, efficient, and suitable for industrialized catalytic reduction system
