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    Home > Active Ingredient News > Endocrine System > Severe hypercalcemia treatment strategy, quick look!

    Severe hypercalcemia treatment strategy, quick look!

    • Last Update: 2021-09-19
    • Source: Internet
    • Author: User
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    The severity of hypercalcemia is different, and the treatment method is also different (see the table below)
    .


    Mild hypercalcemia (<3mmol/L, 12mg/d) can be corrected by fluid replacement


    The development of hypercalcemia is related to the following factors: excessive release of bone calcium, increased calcium absorption by the intestine, or insufficient calcium clearance by the kidneys
    .


    Understanding the cause can help guide the next treatment


    treatment Effective time duration advantage shortcoming
    Conventional treatment
    Normal saline rehydration Hours During rehydration Continuous fluid rehydration Capacity load
    Diuretic, saline combined with loop diuretics Hours During treatment Fast onset Volume load, cardiac decompensation, close monitoring, electrolyte disturbance, inconvenience
    Pamidronate 1-2 days 10-14 days to several weeks Efficient, late onset 20% have fever, hypophosphatemia, hypocalcemia, and less common osteonecrosis of the jaw
    Zoledronate 1-2 days >3 weeks Same as Pamidronate (longer acting time) Same as above
    Calcitonin Hours 1-2 days Fast onset, starting over treatment in severe hypercalcemia Tolerate quickly
    Special treatment
    Oral Phosphoric Acid 24h During use Chronic treatment (with hypophosphatemia)


    The development of hypercalcemia is related to the following factors: excessive release of bone calcium, increased calcium absorption by the intestine, or insufficient calcium clearance by the kidneys
    .


    Understanding the cause can help guide the next treatment


    The severity of hypercalcemia is different, and the treatment method is also different (see the table below)
    .


    Mild hypercalcemia (<3mmol/L, 12mg/d) can be corrected by fluid replacement


    Rehydration

    The development of hypercalcemia is related to the following factors: excessive release of bone calcium, increased calcium absorption by the intestine, or insufficient calcium clearance by the kidneys
    .


    Understanding the cause can help guide the next treatment


    Excessive release of bone calcium, increased absorption of calcium in the intestine, or insufficient calcium clearance by the kidneys Hydration, strong diuresis and calcitonintherapy.


    Dennis L.


    Dennis L.
    Kasper, Anthony S.
    Fauci, Stephen L.
    Hauser, et al, HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, 19th Edition (308-309).
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