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treatment | Effective time | duration | advantage | shortcoming |
Conventional treatment | ||||
Normal saline rehydration | Hours | During rehydration | Continuous fluid rehydration | Capacity load |
Diuretic, saline combined with loop diuretics | Hours | During treatment | Fast onset | Volume load, cardiac decompensation, close monitoring, electrolyte disturbance, inconvenience |
Pamidronate | 1-2 days | 10-14 days to several weeks | Efficient, late onset | 20% have fever, hypophosphatemia, hypocalcemia, and less common osteonecrosis of the jaw |
Zoledronate | 1-2 days | >3 weeks | Same as Pamidronate (longer acting time) | Same as above |
Calcitonin | Hours | 1-2 days | Fast onset, starting over treatment in severe hypercalcemia | Tolerate quickly |
Special treatment | ||||
Oral Phosphoric Acid | 24h | During use | Chronic treatment (with hypophosphatemia) The development of hypercalcemia is related to the following factors: excessive release of bone calcium, increased calcium absorption by the intestine, or insufficient calcium clearance by the kidneys Understanding the cause can help guide the next treatment The severity of hypercalcemia is different, and the treatment method is also different (see the table below) Mild hypercalcemia (<3mmol/L, 12mg/d) can be corrected by fluid replacement Rehydration The development of hypercalcemia is related to the following factors: excessive release of bone calcium, increased calcium absorption by the intestine, or insufficient calcium clearance by the kidneys Understanding the cause can help guide the next treatment Excessive release of bone calcium, increased absorption of calcium in the intestine, or insufficient calcium clearance by the kidneys Hydration, strong diuresis and calcitonintherapy. Dennis L. Dennis L. Kasper, Anthony S. Fauci, Stephen L. Hauser, et al, HARRISON'S PRINCIPLES OF INTERNAL MEDICINE, 19th Edition (308-309). Leave a message here
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