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Shanghai Jiaotong University Deng Zixin's team collaborated to reveal the biosynthetic mechanism of the super antibiotic darobactin

 Last Update: 2022-05-10
 Source: Internet
 Author: User

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Recently, Professor Deng Zixin's team from the School of Life Science and Technology of Shanghai Jiao Tong University and the State Key Laboratory of Microbial Metabolism jointly published a research paper entitled "Radical SAM-dependent ether crosslink in daropeptide biosynthesis" in "Nature Communications", revealing the super antibiotic darobactin for the first time.

Gram-negative bacteria are resistant to most antibiotics due to their special capsular structure

Through further detailed research, the authors confirmed that DarE inserts the oxygen atom of water molecule between two tryptophans through a novel SAM free radical enzyme mechanism to form its key ether bond crosslink

This work was supported by the National Key Research and Development Program, the Natural Science Foundation of China and other projects

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