Shanghai Jiaotong University Hong Liang's group and their collaborators reveal the microscopic mechanism of the hydrogen bond exchange between interfacial water molecules driving biological cryopreservation

Recently, the research group of Professor Hong Liang from the Institute of Natural Sciences/School of Physics and Astronomy of Shanghai Jiao Tong University, the research group of Zhuang Wei from the Fujian Institute of the Structure of Matter, Chinese Academy of Sciences, and the research group of Professor Cheng He from the Dongguan Spallation Neutron Source used neutron scattering and deuteration technology.

Biopreservation is a key engineering problem involving long-term storage and transport from biological macromolecules (protein, DNA, RNA, etc.

This work combines deuteration technology and quasi-elastic neutron scattering experiments to study the motion behavior of water molecules at the interface of nearly 10 different biomolecules and soft matter materials at low temperature, and its dependence on temperature

Zheng Lirong, a doctoral student at the School of Physics and Astronomy, Shanghai Jiao Tong University, is the first author of this article, Liu Zhuo, an assistant researcher at the Academy of Natural Sciences, and Zhang Qiang, a professor at Inner Mongolia University for Nationalities, are the co-first authors.