Recently, Zhu Huanhu’s research team from the School of Life Sciences, ShanghaiTech University used an animal model of Caenorhabditis elegans and found that the monomethyl branched chain fatty acids rich in beef and dairy products can act as a key food nutrition signal to regulate the sphingolipid and mTOR pathways.
Food is one of the most important resources for the growth and development of all animals, including humans
In recent years, biochemists have used mammalian tissue culture cell systems to gradually reveal a series of related signaling pathways (such as mTOR, insulin, AMPK, etc.
In response to these problems, the researchers first took advantage of the long-term survival characteristics of Caenorhabditis elegans in a "starvation state", bypassing the shortcomings of animals that cannot survive when nutrition is deprived, and cultivated the nematodes under severe food shortages.
The regulation of monomethyl branched chain fatty acid on developmental fate was first discovered by Professor Min Han of the University of Colorado in Nematodes.
The findings of Zhu Huanhu’s research team suggest that as a metabolite of the essential amino acid leucine, monomethyl branched-chain fatty acids seem to mediate the nematode’s perception of total food amino acids
Why do animals choose to use monomethyl branched-chain fatty acids to assess the abundance of total amino acids in evolution? Researchers found that nematodes are rich in monomethyl branched chain fatty acids among several food bacteria/intestinal bacteria in nature
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
devcel.
2021.
09.
010
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