Shao Zhihui, Professor of Yunnan University, has made new progress in the field of chiral catalysis and synthesis of chiral natural products / chiral drugs

Recently, the research group of Shao Zhihui, Professor of Yunnan University, has made new progress in the field of chiral catalysis and synthesis of chiral natural products / chiral drugs The research results were published in angew Chem Int ed (DOI: 10.1002 / anie 201901511) The work was jointly completed by Li long, Ph.D candidate and Luo Pengfei, Ph.D candidate Professor Shao Zhihui is the corresponding author Transition metal catalyzed cycloaddition has been widely concerned because of its importance in organic chemistry, pharmaceutical chemistry and material chemistry Most of the reactions are carried out by metal dipole intermediates, involving a electrophilic center and a nucleophilic center, while cycloaddition reactions based on non dipole intermediates are relatively rare, which is still an important scientific problem to be solved in this field Recently, through the development of 2,3-dienolate as a new type of 1,4-amphiphilic reagent and tetracarbon unit, the team has realized the palladium catalyzed asymmetric [4 + 1] cycloaddition reaction for the first time, which provides a new method for the construction of chiral cyclopentene At the same time, by regulating the ligands of palladium catalyst, the research group developed a new mode of [4 + 3] cycloaddition / cross coupling reaction, which provides a new way for the synthesis of functionalized seven membered oxygen heterocycles In addition, the group also tested the antitumor activity of the new compounds in vitro, and found new molecules that can effectively inhibit human gastric cancer cells and cervical cancer cells This work has been supported by the National Natural Science Foundation of China, the Yangtze River scholars and innovation team development plan of the Ministry of education, the University Science and technology innovation team plan of Yunnan Province, the key joint fund project of Yunnan Science and Technology Department Yunnan University and the "Yunling scholars" plan of Yunnan Province.