Shen Zhanlong's group and collaborators reveal that Asian-specific IgG1 memory B cell antigen receptor variants have protective effects on colorectal cancer

? ? ? On March 15, 2022, Shen Zhanlong's research group from the Department of Gastrointestinal Surgery of Peking University People's Hospital and Liu Wanli's research group from the Institute of Immunology, School of Life Sciences, Tsinghua University cooperated to tackle key problems in the regulation of colorectal tumor immunity by IgG1 memory B lymphocytes Important progress has been made in the field of microenvironment research, and the research paper An Asian-Specific Variant in Human IgG1 Represses Colorectal Tumorigenesis by Shaping the Tumor Microenvironment has been published in the Journal of Clinical Investigation, an internationally renowned biomedical journal

? ? ? The importance of T cells in tumor immune evasion and as a target for drug therapy has been recognized, but relatively little research has been done on B cells

? ? ? The researchers conducted epidemiological analysis on a cohort of more than 1,000 colorectal cancer patients and found that patients with tumors homozygous for hIgG1-G396R genotype had significantly improved overall prognosis and progression-free survival, and multi-factor COX risk.

? ? ? The above studies indicate that the hIgG1-G396R variant may be an important protective prognostic factor for patients with colorectal cancer, revealing that hIgG1-G396R has the potential to be used as a prognostic indicator for patients in the field of colorectal cancer.

? ? ? Dr.

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(Peking University People's Gastrointestinal Surgery)