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In a living cell environment, it is very challenging to study the compression of genomic DNA in the nucleus and the dynamic reorganization during physiological processes or disease development
.
This complexity stems from the high compaction required to place approximately 2 meters of genomic DNA into the cell nucleus, which is usually 5 to 10 microns in diameter
Professor Qu Junle from the Research Center for Biomedical Optics and Photonics & School of Physics and Optoelectronic Engineering, Shenzhen University, China, and Professor Paras N.
Prasad from the Institute of Laser, Photonics and Biophotonics, Shenzhen University, published in the Journal of Optical Science and Applications A new paper
.
The State University of New York in Buffalo, USA has developed an alternative strategy based on fluorescence lifetime imaging (FLIM) to overcome the existing limitations of traditional methods
In their study, both FLIM methods were validated in cultured cells.
They compared and analyzed the compaction of gene-rich chromatin domains.
These chromatin domains replicate in the early s phase, while those in the s phase Late copying mainly contains non-coding sequences
.
The data obtained demonstrates the sensitivity of FLIM detection and reveals a significant difference in the degree of compaction of gene-rich and gene-poor libraries in genomic DNA