Shiyi's long skill to make Yi

Hepatitis B is a common common disease that threatens hundreds of millions of people, and the virus, as one of the smallest viruses, leaves many animals helpless.
infects many animals with hepatitis B, and it is estimated that most hosts are helpless to it, even though they have not made much progress for at least tens of thousands of years.
The reason why hepatitis B is so hard to cure is to rely on a mechanism called cccDNA, which simply enters the nucleus of the host cell and is treated by the DNA repair mechanism as a broken DNA repair to form a very stable ring DNA, that is, cccDNA.
cccDNA's presence makes it possible for the HBV to continue to produce, of course, HBV only infects liver cells, is not in a hurry to kill the host is also the reason for its long-term prosperity, those sword-sealed throat virus has long been with the host.
can we learn from the nine yins of hepatitis B used to invent new drugs, especially anti-cancer drugs? Although the death rate of tumors is decreasing year by year, it is still the world's second-largest killer, and most of the current cancer drugs are based on a simple and crude three-light policy.
But tumors are hard to kill completely because they are highly heterogeneous, and almost every cell of tumor tissue is sensitive to a drug, except, of course, for poisons that are highly broad-spectrum and kill even the host.
are drug-resistant clones that survive under the pressure of natural selection, so almost all cancer drugs face drug resistance problems, and cures are still rare events.
If the heterogeneity of the tumor is used and some tumor cells are implanted into an undercover cell similar to hepatitis B cccDNA, it may be available to these tumor cells to continuously produce tumor-killing toxins (e.g. TNF, IFN, etc.).
resistance is mild because the damage to the tumor is less stressful than other tumor cells.
the success of PD-1 drugs in a sense can be seen as amplifying the role of harmful groups in tumor tissue.
of course, some gene therapies have been able to produce stable DNA structures in the nuclei of cells, and current technology can actually introduce exogenic genes into tumor cells.
not a new concept, such as p53 gene therapy or expression tumor antigen tumor vaccine gene therapy such asaduro's CRS-207.
But these tumor gene therapy ideas are similar to targeted therapy, is the introduction of direct killing mechanism, so although the fire because selective killing successfully transferred to these genes of tumor cells, will also face the drug treatment selective killing sensitive cells, leaving drug-resistant cells.
is probably the closest technology to breaking into tumor tissue and reversing parts of tumor cells that heat tumor microenvironment (TME) from cold to hot, but the technology is now slow because of selective issues.
of course, undercover is not necessarily limited to tumor cells, any TME resident cells can be used as a target for united front.
for example, there are now cell therapies that treat cancer with genetically modified blood cells that express killer cytokines, which can also be linked to the immune system because some of them enter TME.
small molecules may have a similar effect.
This year, Chinese immunologist Professor Fu Yang heart found that tumor cells after radiotherapy treatment will have some cell apoptosis, if at the same time inhibit the activity of apoptosis enzyme will cause the secretion of type 1 interferon and activate T cells to kill more tumors.
french team found that low doses of yew alcohol can cause some tumor cells to release interferon and TNF, which indirectly kill more tumors.
if the dose of yew alcohol is too high and the removal of tumor cells capable of producing IFN and TNF is reduced, the undercover agent needs to be there for a long time to make the most of it.
the essence of tumor is different from normal cell ecology, we are still exploring many basic problems of tumor occurrence, development and survival.
, for example, suggest that the brutal treatment of traditional chemotherapy has led tumor cells to begin to resent the TME environment, increasing metastasis pressure.
Billions of years of game accumulation between life is often beyond science and technology, hepatitis B although everyone shouted, but only by three thousand bases can infect so many species hundreds of thousands of years but the entire animal community can not help the survival strategy worthy of our reference.