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A paper published in "Nature-Aging" Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study pointed out that short-term exposure (up to 28 days) is associated with high levels of air pollution.
Cognitive dysfunction in older men is related.
The paper also showed that the negative effects of this short-term air pollution exposure were relatively minor among the subjects taking common prescription pain relievers.
Cognitive decline is common in the elderly, and environmental factors can accelerate this decline, such as exposure to fine particulate matter (PM2.
5) in the air that does not exceed 2.
5 microns in size.
Nevertheless, there is still a lack of research on the impact of short-term air pollution exposure on the cognitive function of the elderly.
Previous studies have also analyzed non-steroidal anti-inflammatory drugs (NSAIDs: a class of drugs that relieve pain and inflammation, such as aspirin) as a potential treatment for cognitive dysfunction and dementia.
However, it has never been studied before whether NSAID can be used as an intervention for the impact of air pollution on cognitive health.
Gao Xu of Peking University in China and his colleagues studied 954 older white men (average age 70) in the Greater Boston area who participated in the Veterans Affairs Normative Aging Study in the United States.
In multiple visits, the author used general cognitive function and Mini Mental State Examination (MMSE) scores to evaluate the cognitive performance of these people.
The authors then compared these data with the local PM2.
5 level on the day of each visit and the average PM2.
5 level 1-4 weeks before the visit.The comparison found that the increase in PM2.
5 levels up to 28 days before the evaluation is related to the decline in the participants' overall cognitive function scores, even if the PM2.
5 level is lower than the level generally considered dangerous (approximately ≤10 μg m−3) .
They also found that study subjects taking NSAID prescription drugs were less adversely affected by short-term air pollution exposure.
The authors concluded that interdisciplinary studies based on larger cohorts and more detailed NSAID use information are still needed to verify the relationship between air pollution exposure and cognitive function, and the possible improvement effect of NSAID on this.
During the 28-day air pollution exposure period, the relationship between PM2.
5 levels and cognitive function, Mini Mental State Examination Score (MMSE), and the probability of occurrence of low MMSE scores.
Source: Gao et al.
©NatureNat Aging | doi: 10.
1038/s43587-021-00060-4
Cognitive dysfunction in older men is related.
The paper also showed that the negative effects of this short-term air pollution exposure were relatively minor among the subjects taking common prescription pain relievers.
Cognitive decline is common in the elderly, and environmental factors can accelerate this decline, such as exposure to fine particulate matter (PM2.
5) in the air that does not exceed 2.
5 microns in size.
Nevertheless, there is still a lack of research on the impact of short-term air pollution exposure on the cognitive function of the elderly.
Previous studies have also analyzed non-steroidal anti-inflammatory drugs (NSAIDs: a class of drugs that relieve pain and inflammation, such as aspirin) as a potential treatment for cognitive dysfunction and dementia.
However, it has never been studied before whether NSAID can be used as an intervention for the impact of air pollution on cognitive health.
Gao Xu of Peking University in China and his colleagues studied 954 older white men (average age 70) in the Greater Boston area who participated in the Veterans Affairs Normative Aging Study in the United States.
In multiple visits, the author used general cognitive function and Mini Mental State Examination (MMSE) scores to evaluate the cognitive performance of these people.
The authors then compared these data with the local PM2.
5 level on the day of each visit and the average PM2.
5 level 1-4 weeks before the visit.The comparison found that the increase in PM2.
5 levels up to 28 days before the evaluation is related to the decline in the participants' overall cognitive function scores, even if the PM2.
5 level is lower than the level generally considered dangerous (approximately ≤10 μg m−3) .
They also found that study subjects taking NSAID prescription drugs were less adversely affected by short-term air pollution exposure.
The authors concluded that interdisciplinary studies based on larger cohorts and more detailed NSAID use information are still needed to verify the relationship between air pollution exposure and cognitive function, and the possible improvement effect of NSAID on this.
During the 28-day air pollution exposure period, the relationship between PM2.
5 levels and cognitive function, Mini Mental State Examination Score (MMSE), and the probability of occurrence of low MMSE scores.
Source: Gao et al.
©NatureNat Aging | doi: 10.
1038/s43587-021-00060-4
