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Shrink tumors by more than 80% AKT targeted protein degradation therapy is expected to treat a variety of cancers

 Last Update: 2021-07-31
 Source: Internet
 Author: User

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AKT is an important target related to a variety of cancers

In this study, scientists used tumor cell lines to screen out protein degradation agents that can target AKT

The researchers screened an AKT protein degradation agent called M21 and tested its anti-cancer activity in mouse models of breast and prostate cancer

▲M21 reduces tumor growth by 90% in a mouse model of prostate cancer (picture source: reference [1])

The researchers also evaluated which cancers are sensitive to this protein degrading agent

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