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Signal Transduct Target Ther: How safe are human umbilical cord mesenchymal stem cells to treat COVID-19 patients?

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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For COVID-19 , there is currently no effective drug treatment
.

Host-directed therapies for potentially abnormal immune responses that cause lung tissue damage, death, or long-term dysfunction in survivors require further clinical evaluation

COVID-19 immune stem cells

The study recruited 18 hospitalized COVID-19 patients (n = 9 in each group)
.

The treatment group received three cycles of intravenous infusion of UC-MSCs (3×107 cells per infusion) on days 0, 3, and 6

No serious adverse events related to the infusion of UC-MSCs were observed during the study
.

Two patients who received UC-MSCs developed transient facial flushing and fever, and one patient developed transient hypoxia 12 hours after UC-MSCs infusion

In summary, the data of the study shows that intravenous infusion of UC-MSCs in patients with moderate to severe COVID-19 is safe and well tolerated
.

A phase 2/3 randomized, controlled, double-blind trial with long-term follow-up is needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve the long-term treatment effect of patients with severe COVID-19

Original source:

Fanping Meng, Ruonan Xu, et al.

Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial in this message

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