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Rheumatoid factor (RF) is an autoantibody against the Fc fragment of IgG
Rheumatoid factor (RF) is an autoantibody against the Fc fragment of IgG
RF has low specificity, and it can also be seen in diseases other than RA
At present, the clinically helpful biomarkers for the diagnosis of RA are mainly RF and antibodies to citrullinated peptides (ACPA)
At present, the clinically helpful biomarkers for the diagnosis of RA are mainly RF and antibodies to citrullinated peptides (ACPA)
Although some other diagnostic tests (especially ACPA) have been widely used clinically, IgM-type RF testing still has a place in clinical practice
Although some other diagnostic tests (especially ACPA) have been widely used clinically, IgM-type RF testing still has a place in clinical practice
Studies have shown that, compared with the high titre ACPA, high titers of RF seems to be more predictive of severe disease course, with interstitial lung disease and vascular performance is more relevant go far outside the joint
Studies have shown that, compared with the high titre ACPA, high titers of RF seems to be more predictive of severe disease course, with interstitial lung disease and vascular performance is more relevant go far outside the joint
RF may have certain predictive value in terms of disease performance and mobility, and the severity of joint erosion
RF may have certain predictive value in terms of disease performance and mobility, and the severity of joint erosion
Rheumatoid nodules and vasculitis are almost only seen in RF-positive patients; these manifestations are associated with increased mortality
Rheumatoid nodules and vasculitis are almost only seen in RF-positive patients; these manifestations are associated with increased mortality
It can be seen that there is a certain correlation between rheumatoid factor and RA disease severity and progression
It can be seen that there is a certain correlation between rheumatoid factor and RA disease severity and progression
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