Significant progress has been made in the pathogenesis of depression

Significant progress has been made in the pathogenesis of depression

Research on the pathogenesis of depression has made important progress.

Science and Technology Daily reporter Wu Changfeng

The reporter learned from the University of Science and Technology of China that Zhou Jiangning’s research group used genetic manipulation of mice, combined with techniques such as behavior, patch clamp, chemical genetics, and in vivo optical fiber recording, and found that: The excitatory postsynaptic protein PSD-93 plays an important role in the pathogenesis of depression
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Related results were published online on September 18 in Acta Neuropathology, a well-known journal of neuropathology

Depression has become one of the major diseases affecting human life, but its pathogenesis is still unclear
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The onset of depression caused by stress is one of the classic hypotheses

Researchers first confirmed the co-localization of PSD-93 and CRH
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Next, viral infection was used to manipulate the expression level of PSD-93 in CRH neurons, and it was found that overexpression of PSD-93 can cause depression-like behavior in mice, while reducing the expression level of PSD-93 can produce an antidepressant effect

This study revealed that PSD-93 of the hypothalamic paraventricular nucleus plays an important role in the pathogenesis of depression and explored possible mechanisms
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This discovery promotes the understanding of the neural basis of hypothalamic excitatory synaptic disorders in depression, provides direct evidence for the synaptic regulation of the hypothalamic-pituitary-adrenal axis in depression, and promotes excitement in the onset of depression The integration of sexual synapse hypothesis, stress hypothesis and inflammatory immune hypothesis