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Editor’s note iNature is China’s largest academic official account.
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us.
Due to the rapid increase in new cases of iNature, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention, and the pathogen was identified as SARS-CoV-2.
As of now (April 21, 2021), according to real-time statistics released by Johns Hopkins University, the cumulative number of confirmed cases of new coronary pneumonia worldwide has exceeded 143.
97 million, and the death toll has reached 3.
06 million.
These figures are updated every day and are expected to increase further.
Acupuncture is an important part of traditional Chinese medicine and has been widely used to treat inflammatory diseases.
During the COVID-19 epidemic, acupuncture has been used as a complementary treatment for COVID-19 in China.
However, the underlying mechanism of acupuncture in the treatment of COVID-19 remains unclear.
On April 19, 2021, Tianjin Public Security Hospital cooperated with China Academy of Chinese Medical Sciences, Hebei College of Traditional Chinese Medicine, Tianjin Nankai Hospital, and Tianjin University of Traditional Chinese Medicine First Affiliated Hospital.
Zhang Kai, Tang Qilin and Wang Pengqian jointly communicated in Briefings in Bioinformatics ( IF=8.
99) Published online research paper titled "Is acupuncture effective in the treatment of COVID-19 related symptoms? Based on bioinformatics/network topology strategy".
The research is based on bioinformatics/topology and through text mining, Bioinformatics and network topology have systematically revealed the multi-target mechanism of acupuncture and moxibustion in the treatment of COVID-19.
The study identified two active compounds and 180 protein targets produced after acupuncture.
A total of 522 Gene Ontology and acupuncture-related COVID-19 categories were identified, and 61 pathways were screened according to KEGG.
The research results show that acupuncture treatment of COVID-19 is related to suppressing inflammatory stress, improving immunity and regulating nervous system functions, including activation of neuroactive ligand-receptor interactions, calcium signaling pathways, cancer pathways, and viral carcinogenesis.
Staphylococcus aureus infection and so on.
The study also found that acupuncture may have more benefits for COVID-19 patients suffering from cancer, cardiovascular disease and obesity.
This study revealed for the first time the multiple synergistic mechanisms of acupuncture and moxibustion on COVID-19.
Acupuncture may play a positive role in the treatment of COVID-19 and is worthy of further promotion and application.
These results may help solve this pressing problem facing the world today.
Due to the rapid increase in new cases, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention.
The new coronavirus infection is believed to be transmitted from animals, and the pathogen has been identified as SARS-CoV-2.
As of January 2020, it is suspected that the initially infected patient was infected with the virus through human-to-human transmission.
Due to the rapid increase in new cases, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention, and the pathogen was identified as SARS-CoV-2.
As of now (April 21, 2021), according to real-time statistics released by Johns Hopkins University, the cumulative number of confirmed cases of new coronary pneumonia worldwide has exceeded 143.
97 million, and the death toll has reached 3.
06 million.
These figures are updated every day and are expected to increase further.
Due to the current lack of effective drugs, a series of basic and clinical studies involving COVID-19 have been conducted to explore and evaluate effective therapies for SARS-CoV-2.
It is worth noting that a large number of COVID-19 patients in China have received integrated traditional Chinese and Western medicine treatment.
In addition, during the COVID-19 epidemic, TCM experts participated in the entire treatment process, and TCM was also included in the diagnosis and treatment guidelines for COVID-19.
In China, acupuncture, Chinese patent medicine and other traditional Chinese medicine therapies are also widely used to treat and prevent COVID-19.
SARS-CoV-2 may cause fatal inflammation and acute lung injury.
Symptoms of high inflammation are manifested in some COVID-19 patients, similar to cytokine storms.
The content of pro-inflammatory cytokines (such as IL-1, IL-6, IL-8, IL-12) increases sharply, exacerbating the progression of the disease.
Acupuncture has been widely used in all aspects of health in history, the purpose is to promote the physiological recovery of diseases, which has also been proven to be safe.
Acupuncture intervention has been proven to actively alleviate inflammation by inhibiting inflammatory cytokines (such as IL-6, IL-1β, TNF-α, etc.
), activating cholinergic anti-inflammatory pathways and regulating immunity.
In addition, in animal models, electroacupuncture can significantly reduce the levels of TNF-α and IL-1β in bronchoalveolar lavage fluid.
Similarly, another study showed that acupuncture can alleviate the inflammatory response triggered by chronic obstructive pulmonary disease (COPD), and then protect lung function by reducing cell inflammation and the production of TNF-α and IL-8.
In addition, electroacupuncture can increase the ratio of CD4 + T cells/CD8 + T cells in experimental autoimmune encephalitis rats, and restore the balance of Th1/Th2/Th17/Treg Th cell subsets.
Systematic reviews and/or meta-analysis have shown that acupuncture is effective for acute pancreatitis, chronic obstructive pulmonary disease, osteoarthritis, etc.
Functionally speaking, acupuncture therapy can relieve the patient's bad mood, relieve symptoms such as cough, dyspnea, abdominal pain, nausea, vomiting and fatigue, and play a role in the prevention, treatment and rehabilitation of COVID-19.
In particular, the RCT meta-analysis showed that acupuncture is an effective adjuvant non-drug treatment that can improve the symptoms of patients receiving respiratory diseases (such as asthma and COPD).
This also provides a basis for further research on the feasibility of acupuncture for the treatment of COVID-19-related symptoms.
However, the therapeutic mechanism of acupuncture treatment for COVID-19 is still unclear.
Recent related studies have proved that acupuncture involves multiple systems of the human body and has multi-target therapeutic effects.
Therefore, there is an urgent need to introduce novel research ideas into the potential mechanism of acupuncture.
In this research, the aim is to reveal the molecular mechanism of acupuncture and moxibustion against COVID-19 through bioinformatics, network topology and network pharmacology methods, so as to further deepen the understanding of the therapeutic nature of acupuncture and moxibustion for COVID-19.
The study identified two active compounds and 180 protein targets produced after acupuncture.
A total of 522 Gene Ontology and acupuncture-related COVID-19 categories were identified, and 61 pathways were screened according to KEGG.
The research results show that acupuncture treatment of COVID-19 is related to suppressing inflammatory stress, improving immunity and regulating nervous system functions, including activation of neuroactive ligand-receptor interactions, calcium signaling pathways, cancer pathways, and viral carcinogenesis.
Staphylococcus aureus infection and so on.
The study also found that acupuncture may have more benefits for COVID-19 patients suffering from cancer, cardiovascular disease and obesity.
This study revealed for the first time the multiple synergistic mechanisms of acupuncture and moxibustion on COVID-19.
Acupuncture may play a positive role in the treatment of COVID-19 and is worthy of further promotion and application.
These results may help solve this pressing problem facing the world today.
Reference message: https://academic.
oup.
com/bib/advance-article/doi/10.
1093/bib/bbab110/6235963
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us.
Due to the rapid increase in new cases of iNature, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention, and the pathogen was identified as SARS-CoV-2.
As of now (April 21, 2021), according to real-time statistics released by Johns Hopkins University, the cumulative number of confirmed cases of new coronary pneumonia worldwide has exceeded 143.
97 million, and the death toll has reached 3.
06 million.
These figures are updated every day and are expected to increase further.
Acupuncture is an important part of traditional Chinese medicine and has been widely used to treat inflammatory diseases.
During the COVID-19 epidemic, acupuncture has been used as a complementary treatment for COVID-19 in China.
However, the underlying mechanism of acupuncture in the treatment of COVID-19 remains unclear.
On April 19, 2021, Tianjin Public Security Hospital cooperated with China Academy of Chinese Medical Sciences, Hebei College of Traditional Chinese Medicine, Tianjin Nankai Hospital, and Tianjin University of Traditional Chinese Medicine First Affiliated Hospital.
Zhang Kai, Tang Qilin and Wang Pengqian jointly communicated in Briefings in Bioinformatics ( IF=8.
99) Published online research paper titled "Is acupuncture effective in the treatment of COVID-19 related symptoms? Based on bioinformatics/network topology strategy".
The research is based on bioinformatics/topology and through text mining, Bioinformatics and network topology have systematically revealed the multi-target mechanism of acupuncture and moxibustion in the treatment of COVID-19.
The study identified two active compounds and 180 protein targets produced after acupuncture.
A total of 522 Gene Ontology and acupuncture-related COVID-19 categories were identified, and 61 pathways were screened according to KEGG.
The research results show that acupuncture treatment of COVID-19 is related to suppressing inflammatory stress, improving immunity and regulating nervous system functions, including activation of neuroactive ligand-receptor interactions, calcium signaling pathways, cancer pathways, and viral carcinogenesis.
Staphylococcus aureus infection and so on.
The study also found that acupuncture may have more benefits for COVID-19 patients suffering from cancer, cardiovascular disease and obesity.
This study revealed for the first time the multiple synergistic mechanisms of acupuncture and moxibustion on COVID-19.
Acupuncture may play a positive role in the treatment of COVID-19 and is worthy of further promotion and application.
These results may help solve this pressing problem facing the world today.
Due to the rapid increase in new cases, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention.
The new coronavirus infection is believed to be transmitted from animals, and the pathogen has been identified as SARS-CoV-2.
As of January 2020, it is suspected that the initially infected patient was infected with the virus through human-to-human transmission.
Due to the rapid increase in new cases, the 2019 Coronavirus Disease (COVID-19) quickly attracted global attention, and the pathogen was identified as SARS-CoV-2.
As of now (April 21, 2021), according to real-time statistics released by Johns Hopkins University, the cumulative number of confirmed cases of new coronary pneumonia worldwide has exceeded 143.
97 million, and the death toll has reached 3.
06 million.
These figures are updated every day and are expected to increase further.
Due to the current lack of effective drugs, a series of basic and clinical studies involving COVID-19 have been conducted to explore and evaluate effective therapies for SARS-CoV-2.
It is worth noting that a large number of COVID-19 patients in China have received integrated traditional Chinese and Western medicine treatment.
In addition, during the COVID-19 epidemic, TCM experts participated in the entire treatment process, and TCM was also included in the diagnosis and treatment guidelines for COVID-19.
In China, acupuncture, Chinese patent medicine and other traditional Chinese medicine therapies are also widely used to treat and prevent COVID-19.
SARS-CoV-2 may cause fatal inflammation and acute lung injury.
Symptoms of high inflammation are manifested in some COVID-19 patients, similar to cytokine storms.
The content of pro-inflammatory cytokines (such as IL-1, IL-6, IL-8, IL-12) increases sharply, exacerbating the progression of the disease.
Acupuncture has been widely used in all aspects of health in history, the purpose is to promote the physiological recovery of diseases, which has also been proven to be safe.
Acupuncture intervention has been proven to actively alleviate inflammation by inhibiting inflammatory cytokines (such as IL-6, IL-1β, TNF-α, etc.
), activating cholinergic anti-inflammatory pathways and regulating immunity.
In addition, in animal models, electroacupuncture can significantly reduce the levels of TNF-α and IL-1β in bronchoalveolar lavage fluid.
Similarly, another study showed that acupuncture can alleviate the inflammatory response triggered by chronic obstructive pulmonary disease (COPD), and then protect lung function by reducing cell inflammation and the production of TNF-α and IL-8.
In addition, electroacupuncture can increase the ratio of CD4 + T cells/CD8 + T cells in experimental autoimmune encephalitis rats, and restore the balance of Th1/Th2/Th17/Treg Th cell subsets.
Systematic reviews and/or meta-analysis have shown that acupuncture is effective for acute pancreatitis, chronic obstructive pulmonary disease, osteoarthritis, etc.
Functionally speaking, acupuncture therapy can relieve the patient's bad mood, relieve symptoms such as cough, dyspnea, abdominal pain, nausea, vomiting and fatigue, and play a role in the prevention, treatment and rehabilitation of COVID-19.
In particular, the RCT meta-analysis showed that acupuncture is an effective adjuvant non-drug treatment that can improve the symptoms of patients receiving respiratory diseases (such as asthma and COPD).
This also provides a basis for further research on the feasibility of acupuncture for the treatment of COVID-19-related symptoms.
However, the therapeutic mechanism of acupuncture treatment for COVID-19 is still unclear.
Recent related studies have proved that acupuncture involves multiple systems of the human body and has multi-target therapeutic effects.
Therefore, there is an urgent need to introduce novel research ideas into the potential mechanism of acupuncture.
In this research, the aim is to reveal the molecular mechanism of acupuncture and moxibustion against COVID-19 through bioinformatics, network topology and network pharmacology methods, so as to further deepen the understanding of the therapeutic nature of acupuncture and moxibustion for COVID-19.
The study identified two active compounds and 180 protein targets produced after acupuncture.
A total of 522 Gene Ontology and acupuncture-related COVID-19 categories were identified, and 61 pathways were screened according to KEGG.
The research results show that acupuncture treatment of COVID-19 is related to suppressing inflammatory stress, improving immunity and regulating nervous system functions, including activation of neuroactive ligand-receptor interactions, calcium signaling pathways, cancer pathways, and viral carcinogenesis.
Staphylococcus aureus infection and so on.
The study also found that acupuncture may have more benefits for COVID-19 patients suffering from cancer, cardiovascular disease and obesity.
This study revealed for the first time the multiple synergistic mechanisms of acupuncture and moxibustion on COVID-19.
Acupuncture may play a positive role in the treatment of COVID-19 and is worthy of further promotion and application.
These results may help solve this pressing problem facing the world today.
Reference message: https://academic.
oup.
com/bib/advance-article/doi/10.
1093/bib/bbab110/6235963