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Significantly reduce liver fibrosis mRNA therapy shows therapeutic potential

 Last Update: 2021-09-13
 Source: Internet
 Author: User

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Today, CureVac announced that the company’s preclinical study of its mRNA therapy encoding hepatocyte nuclear factor 4α (HNF4A) was published in the peer-reviewed Journal of Hepatology
.

It is reported that this study provides preclinical data for the first time, proving the applicability of mRNA therapy encoding HNF4A transcription factor in the treatment of liver fibrosis and cirrhosis

Liver fibrosis is characterized by the formation of scar tissue in the liver, which causes gradual impairment of liver function
.

This process can evolve into irreversible advanced liver cirrhosis, leading to liver failure or cancer

The research was conducted jointly by the company's researchers and experts from Hannover Medical School in Germany
.

In this study, the researchers used lipid nanoparticles (LNP) to deliver mRNA therapy encoding HNF4A in 4 independent mouse models of liver disease

▲Research icon (picture source: reference [2])

Reference materials:

[1] CureVac Preclinical Data Demonstrates Significant Reduction of Liver Fibrosis with mRNA Therapeutic.

[2] Yang et al.

(The original text has been deleted)

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