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On April 18, the journal PLoS Genetics published a research paper entitled The SnRK2 kinases modulate miRNA found in Arabidopsis by Zhu Health Research Group of the Shanghai Research Center for Plant Adversity Biology, Shanghai Institute of Life Sciences, Chinese Academy of Sciences.
the study revealed that SnRK2, a key protein kinase for plant ABA signal transductivity and penetration stress, was involved in the regulation of miRNA biosynthesis.
microRNA (miRNA) is a small, non-coding RNA that is widely present in plants and animals with a length of 20-24 nucleotides.
by regulating the shearing and translation of mRNA, miRNA is involved in many biological processes such as plant growth and development, coercive response, and so on.
III RNA enzymes DCL1, zinc finger protein SE, and double-stranded RNA binding protein HYL1 are the core components of miRNA synthesis complexes.
the plant hormone shedding acid and osmotic stress response pathways can affect the accumulation of miRNA, but the detailed molecular mechanisms are not clear.
Zhu Health Research Group found that the core composition of the plant hormone shedding acid and osmotic stress response pathway SnRK2 protein kinase regulates the core composition of the miRNA synthesis pathway and regulates the synthesis of miRNA.
in the model plant amoeba, the SnRK2 protein kinase family has 10 members (SnRK2.1-SnRK2.10).
, snrk2.2/2.3/2.6 tri mutants are insensitive to ABA, while snrk2 ten mutants missing from all SnRK2 members lack the ability to adapt to osmosis coercion and are sensitive to osmosis stress.
The Zhu Health Research Group found that in snrk 2.2/2.3/2.6 mutants, miRNAs such as miR160 decreased, corresponding to increased pregenitor (pri-miRNA) of miRNA, and target gene expression.
the HYL1 protein content decreased in snrk2 tri mutants and ten mutants.
further studies suggest that HYL1 and SE proteins may be phosphate substrates of SnRK2 protein kinases.
the study found the important role of SnRK2 protein kinase in miRNA synthesis, and initially revealed the molecular mechanisms of ABA and osmotic stress to regulate miRNA synthesis.
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