Solution of point liquid system for high precision microfluidic chip

Microfluidic chip integrates a series of basic operation units involved in chemical and biological fields, such as sample preparation, reaction, separation, detection, etc into a μ M-level chip At the same time, it combines and integrates the operation steps through the channel size, curvature, micro valve, cavity design, etc Microfluidic chip is portable, low energy consumption, easy to manufacture and grasp, and can meet the needs of life science for biological sample separation and analysis with low dose, high sensitivity and fast speed, so that the entire detection integration is miniaturized and automated Because of its great potential in biology, chemistry, medicine and other fields, it has developed into a new interdisciplinary research field of biology, chemistry, medicine, fluid, electronics, materials, machinery and other disciplines Characteristics of microfluidic chip: ① a chip can form a multi-functional integrated system and a large number of composite systems of micro total analysis system Microfluidic chip has a strong integration: more and more unit components are integrated into the chip, and the scale of integration is growing, which can process a large number of samples in parallel ② It is characterized by high throughput, fast analysis speed, low energy consumption and material consumption, and small pollution The amount of reagents needed for the analysis of the sample is as low as a few μ L, and the volume of the substance to be analyzed is at NL or PL level The advantages of cheap, safe and microfluidic analysis system in miniaturization, integration and portability provide a very broad prospect for its application in biomedical research, drug synthesis and screening, environmental monitoring and protection, health quarantine, judicial identification, biological reagent detection and many other fields The biological sample, reaction solution and analysis sample loaded on the microfluidic chip are as low as NL level, and have high precision requirements ① It is directly related to the sensitivity and accuracy of microfluidic chip test results to accurately load quantitative samples into the liquid chamber of a specific chip within the given error range; ② most of the reaction liquid costs are high, and the control of sample adding accuracy can not only improve the accuracy and reliability of the product, but also greatly save the product cost This puts forward high requirements for production equipment At present, the commonly used equipment are: micro sample feeder, pipette, traditional syringe pump, etc The accuracy and stability of these equipment are low, some of them can not realize automatic integration, and they are mainly suitable for manual sampling in laboratories with low technical requirements, with low working efficiency, which are often not adopted in production lines For μ L level, even NL and PL level high-precision point samples, the technical team of Guangzhou feisheng precision equipment Co., Ltd has introduced the American ivek ceramic micropump technology since 2008 to provide high-precision microfluidic system solutions for customers in China and Asia American ivek company is a 40 year old high-tech company located in the northeast of the United States It focuses on R & D and manufacturing of various fluid dispensing, enzyme dispensing, reagent filling, marking machine, spraying, and fluid control process automation Its products are famous for micro, high precision and extreme repeatability It has served many well-known European and American multinational companies, and its industries are spread over biochemical technology and biochip , pharmaceutical, medical equipment, semiconductor and other high-tech industries
Through the system integration of ivek microfluidic control system in the United States, the technical team of Guangzhou feisheng company has successfully provided a variety of precision fluid control system solutions for multinational biological companies in Europe and the United States in Asia and local enterprises in China Our successful application cases in bioengineering include: microfluidic chip point fluid scribing, biochip micro point fluid, ground-based enzyme dropping machine It is widely used in the development and manufacture of microfluidic chip, diagnostic reagent / diagnostic test strip, blood glucose meter test strip, nucleic acid technology chip detection, drug support spraying, blood collection spraying, pre filling / pre filling syringe spraying and so on According to the application requirements of different customers, Guangzhou feisheng company provides a variety of liquid point platforms and micro pump systems The micro fluid control system of Guangzhou feisheng company is mainly composed of two parts: (1) online or offline point fluid platform; (2) FS h-ap / ds3020 / or multi-channel micro fluid pump system The on-line liquid point platform is driven by high-precision servo and equipped with CCD vision detection device to detect and locate automatically Small, medium and large automation platforms are available to meet the needs of different production lines FS H -AP／DS3020 / Or multi-channel micro fluid pump system, all adopt precision sapphire grade ceramic pump technology, which has the characteristics of high accuracy, corrosion resistance, wear resistance and pollution-free It is widely used in fluid control, maintenance free design, extreme stability and reliability, production rate, making FS h-ap / ds3020/ The multi-channel micro pump system has become a high cost-effective fluid control system for liquid dispensing, marking and filling System composition: platform fsh-ap micropump system ds3020 multichannel micropump system features: ● Small, medium and large automatic platforms can be selected to meet the needs of different production lines ● the platform system adopts high-precision servo drive, with CCD visual detection device, automatic detection and positioning ● high precision ceramic pump, sapphire grade, wear-resistant, pollution-free ● micro point liquid, from μ l to NL grade ● high precision, up to 0.1% CV precision ● Maintenance free design, extremely stable and reliable ● high yield, bringing greater value to customers ● successful cases, widely used by well-known multinational companies ● applicable to micro spot solution, marking, filling, spraying, and other applications requiring high-precision micro spot solution The following are several typical customer case sharing Case share 1: a well-known biochip listed company, focusing on the research and development of biochip and mass production In the early stage (before 2007) of the company, traditional syringe pumps of other brands were used for manual production, resulting in low precision and poor product stability The company has been looking for a better micropump for liquid dispensing until the second half of 2007 through the exhibition to find the technical team of feisheng company, which visited the company and got a detailed understanding The production process of the customer's products is introduced, and the single channel ds3020 micro pump point liquid system is recommended Ds3020 adopts American ivek high precision ceramic micropump technology, the system resolution reaches 2nl, and is equipped with ultra-fine Teflon catheter and special liquid point needle After liquid point test and verification, the liquid point accuracy is far higher than the existing syringe pump of customers Ds3020 point liquid quantity can be input and modified on the controller digitally The interface of the device is rich, and it can be started by foot, semi-automatic and fully automatic production Therefore, the customer purchased two ds3020 micro pump liquid point system in advance to eliminate the syringe pump of the original line After several months of mass production, the accuracy and stability of the products have been greatly improved, so the customer purchased more than 20 ds3020 liquid point systems before and after, and replaced all the old syringe pumps In 2013, the customer prepared to go public, and its biochip market expanded rapidly, and the research and development of new products accelerated It began to develop a new generation of microfluidic chips, with the liquid point volume required to be at the nano upgrading level and the multi-channel liquid point system required The technical team of Guangzhou feisheng had a detailed technical exchange with customers, and recommended MS2000 multi-channel system + high-precision XYZ three-dimensional platform The micro pump point liquid resolution of the multi-channel system reached 2nl, which can drive 2-32 channels to point liquid at the same time, thus greatly improving the production efficiency After a long time of comparative verification, the customer confirmed that the system provided by feisheng company is stable and reliable, and can be fully used in batch automatic production of micro point liquid system From 2013 to 2018, the customer successively purchased 8 sets of MS2000 multi-channel system + high-precision XYZ 3D platform for mass production of biochips From 2007 to 2018, Guangzhou feisheng company witnessed the rapid development of the customer from dozens of people, hundreds of people, to the listed / thousands of people The single channel and multi-channel precision micro pump liquid point system + precision automation platform provided by Guangzhou feisheng company provides a strong equipment guarantee for the research and development and manufacturing of microfluidic chips of the customer The success of customers is the success of Guangzhou feisheng company Case share 2: a well-known biochip company in Jiangsu and Zhejiang Province, the range of liquid point volume is 1-2 μ L, which requires 25 channels of liquid point online, with a precision of 1% Guangzhou feisheng company has provided the customer with multiplex 25 channel point liquid system + XYZ high precision point liquid platform The point liquid system adopts high-resolution servo control slideway, each slideway can drive up to 12 micro ceramic pumps at the same time, The resolution can reach 5nl, and the point liquid quantity of μ L level and below can be set by program The precision can reach 0.2%, which fully meets the application requirements of precise micro point liquid The online dispensing platform provided by feisheng company can automatically load and unload the material card The platform is equipped with high-definition CCD camera, XYZ three-axis precision screw rod, ultra-fine catheter and special needle With 25 channel precision dispensing system, it provides customers with a microfluidic biochip batch automation production system solution The customer has always been recognized as one of the well-known enterprises in the microfluidic chip industry The multiple automatic microfluidic systems provided by feisheng company produce microfluidic chips continuously and stably for customers in the background Guangzhou feisheng precision equipment Co., Ltd is a high-tech enterprise specialized in precise fluid control system and solutions The company has rich experience in micro fluid injection, filling, marking, dispensing, spraying and automatic design and manufacturing It is a well-known micro fluid control system company, serving high-tech enterprises in China and Asia, and creating more value for customers with technology Examples of other customers we serve: BD company, Shenzhen Ruilai biology, sannuo biology, Hangzhou Aikang biology, Hangzhou weice, Weigao group, Tianjin micro nano core, Ningbo Meikang, Shenzhen Jinrui biology, Taiwan Guangbao biology, etc.