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Figure 1. The protein loading and release capacity and biological effects of SCPAPPy conductive hydrogel nerve conduit With funding from the National Natural Science Foundation of China (approval number: 81830040), Professor Zhang Zhijun’s research group from Southeast University proposed a new therapy for repairing peripheral nerve damage with microfluidic hollow fibers combined with non-invasive electromagnetic induction and controlled-release nerve growth factor. "Microfluidic Hollow Fiber with Improved Stiffness Repairs Peripheral Nerve Injury through Non-invasive Electromagnetic Induction and Controlled Release of NGF" as the title, in 2021 Published online on August 15 in Chemical Engineering Journal Peripheral nerve injury (PNI) can lead to motor, sensory and autonomic nerve function obstacles and muscle atrophy, and its repair is a clinical problem that needs to be solved urgently Although autologous nerve transplantation has been widely used to replace damaged nerves to restore nerve function, the limited donor source and potential risks of neuroma have restricted further applications Professor Zhang Zhijun’s research group cooperated with Tsinghua University, Nanjing Normal University, Nantong University and other units to construct a triple-layered structure consisting of sodium alginate (SA), calcium chloride (Ca 2+ ), polyacrylamide (PA) and polypyrrole (PPy). The combined pulsed magnetic field non-invasively stimulates the conductive nerve conduit through magnetoelectric induction, which can promote the migration and proliferation of Schwann cells and the secretion of endogenous NGF This research provides new theories and technologies for the treatment of peripheral nerve injury through the combination of medicine and engineering and interdisciplinary collaboration and innovation
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