Southern Medical University Cell publication: The important role of lysosomes in the multidirectional differentiation of mesenchymal stem cells

The research team of Bai Xiaochun and Zou Zhipeng of Southern Medical University found that lysosomes play an important regulatory role in the multidirectional differentiation of mesenchymal stem cells.

In the traditional sense, lysosomes are "garbage disposal stations" for recycling and processing waste materials within cells, but recent studies have shown that they also have multiple functions such as regulating cell membrane repair, cell metabolism and immune response

Vangl2 is a key component of the planar cell polarity signaling pathway, and it is located in the plasma membrane in polar epithelial cells

This research system explains the key role of lysosomes in the multidirectional differentiation of mesenchymal stem cells, reveals the important function of Vangl2 to self-limit CMA lysosomal activity through the LAMP-2A signaling pathway, and also suggests precise control through methods such as gene editing The expression of Vangl2 and CMA lysosomal activity may provide potential therapeutic targets for the use of mesenchymal stem cells to prevent and treat related diseases such as osteoporosis, bone defect and bone metabolism imbalance

Paper link:

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