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    Home > Food News > Nutrition News > Space flight promotes opportunities for stem cell science, biomanufacturing, and disease modeling

    Space flight promotes opportunities for stem cell science, biomanufacturing, and disease modeling

    • Last Update: 2022-01-09
    • Source: Internet
    • Author: User
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    The secret to producing large numbers of stem cells more efficiently may lie in the near-zero gravity conditions in space
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    Scientists at Cedars-Sinai report that microgravity may promote the rapid mass production of stem cells, thereby contributing to life saving on earth

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    A paper led by the Cedars Sinai team and published in "Stem Cell Reports" ("Low Earth Orbit Regenerative Medicine Biomanufacturing") highlights the key opportunities discussed at the 2020 Space Biomanufacturing Symposium to expand space stem cell manufacturing
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    According to Cedars-Sinai's paper, attendees at the December Virtual Space Symposium identified more than 50 potential business opportunities for biomanufacturing work in space

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    The most promising technologies fall into three categories: disease models, biological manufacturing, and stem cell-derived products

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    The newly published Stem Cell Report summarizes the outlook: "The seminar will launch a sustainable market roadmap for regenerative medical biomanufacturing in space

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    The author points out that in the past ten years, the International Space Station National Laboratory (ISS National Lab) has supported space research in the fields of tissue engineering and regenerative medicine
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    "This preliminary research and development provides important insights into how to use microgravity to advance space biological manufacturing, thereby benefiting human life and commercial enterprises on Earth

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    " A new understanding of the basic aspects of body cell behavior, cell-cell interaction, tissue development and regeneration

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    In addition, “the groundbreaking bioengineering experiments and ground research carried out on the International Space Station have proven that microgravity can study new features that cannot be achieved under normal gravity conditions, including changes in stem cell proliferation and differentiation

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    The Space Biomanufacturing Symposium was established as the first step to develop a sustainable market roadmap for low-Earth Orbit (LEO) space biomanufacturing
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    The author pointed out that biomanufacturing, that is, the use of biological materials such as microorganisms to produce substances and biological materials suitable for preclinical, clinical and therapeutic applications, can be more efficient under microgravity conditions

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    "We found that space flight and microgravity bio-manufacturing is an ideal place because it has many very special properties of biological tissues and cellular biological processes that can help mass production or other products that you can't be on earth," Stem Cell Biologist Dr.
    Arun Sharma said he is a research scientist and the head of the Cedars-Sinai Council Regenerative Medicine Institute, the Smidt Heart Institute, and the new research laboratory of the Department of Biomedical Sciences

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    "In the past 20 years, regenerative medicine has made significant progress, and space technology has also made exponential progress, which provides new opportunities for entering and commercializing space

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    "

    Among the 50 potential business opportunities identified, three are the most promising areas; disease modeling, stem cells and stem cell-derived products, and biomanufacturing
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    Disease modeling is a method used by scientists to study diseases and possible treatments by duplicating fully functional structures-whether using stem cells, organoids (microscopic 3D structures grown from human stem cells similar to human tissue), or Other organizations

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    Researchers have found that once the body is exposed to a low-gravity environment for a long time, it will accelerate bone loss and aging

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    The researchers wrote in their paper: ".
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    This unique opportunity to separate the stress caused by continuous microgravity can provide important insights for studying the aging process and disease progression

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    " "Relevant space research data shows that humans During the process of adapting to space flight, as well as the process of re-adaptation after returning to Earth, there will be major physiological changes

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    By establishing a disease model based on this accelerated aging process, research scientists can better understand the aging process and the mechanism of disease progression
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    "This work can not only help astronauts, but it can also lead to American manufacturing skeletal structure or skeletal muscle structure that can be applied to diseases such as osteoporosis and other forms of accelerated bone aging and muscle waste of people's experience on Earth," Sharma said that he is the corresponding author of the paper

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    Another topic that was highly discussed at the seminar was biomanufacturing, which is the use of manufacturing processes to produce materials such as tissues and organs
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    3D printing is one of the core technologies of biological manufacturing

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    One of the main problems in producing these materials on Earth involves gravity-induced density, which makes it difficult for cells to expand and grow

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    Since there is no gravity and density in space, scientists hope they can use 3D printing to print unique shapes and products, such as organoids or heart tissue, in a way that cannot be replicated on Earth

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    The review stated: "Discussions on biomanufacturing cover a variety of opportunities, including tissue manufacturing for disease modeling, testing and maturation of biomanufacturing materials, and improved manufacturing processes for biomaterials and biomanufacturing components
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    "The collective demand for new methods of producing implants, tissues and organs is a matter of public concern.
    Government agencies have the opportunity to invest resources and use a unique environment, such as a leo-based platform, to advance the field

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    The third type of research focuses on the production of stem cells and understanding how microgravity affects some basic characteristics of stem cells
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    Some of these characteristics include potential (the ability of stem cells to renew themselves) and differentiation (the ability of stem cells to transform into other types of cells)

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    Understanding some of the effects of space flight on stem cells may lead to better ways to create large numbers of cells without gravity
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    The author points out that there are two main customer groups for stem cells and stem cell-derived products

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    First are those who use stem cells as research tools, and second are those who use stem cells for treatment

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    The authors of the workshop pointed out that participants generally believed that in the short term, the greatest return on investment would come from data that could be transformed into improved terrestrial processes, products, and tools

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    “However, participants believe that, ultimately, the mass production of certain types of stem cells and stem cell-derived products can benefit from production based on low-carbon orbital facilities, and the low-carbon orbital environment can give certain advantages that cannot be replicated in the terrestrial environment.

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    Scientists from Cedars-Sinai will work with NASA and private contractor space Tango to send stem cells into space early next year to test whether it is possible to produce stem cells in large quantities in a low-gravity environment
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    Sharma said: "Although we are still in the exploratory stage of some research, this is no longer the field of science fiction

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    " "In the next five years, we may see such a situation, we can find it on Earth It’s impossible to make cells or tissues

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    I think this is very exciting

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    As the author of the outlook reports, “it’s time to use low orbit for research and development to prove the value of space-based biomanufacturing and its benefits to mankind
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    " This will make a strong space biomanufacturing market.
    The required investment becomes possible, and this seminar is the first step in developing this future

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    "

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