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A few days ago, Merus announced the latest clinical trial results of its research bispecific antibody therapy zenocutuzumab at the ASCO annual meeting
In patients with NRG1 fusion-positive tumors, the NRG1 gene that expresses neuregulin is fused with other genes, resulting in abnormal expression of neuregulin, which promotes the occurrence and proliferation of cancer
In addition, this antibody also has the effect of enhancing antibody-dependent cell-mediated cytotoxicity (ADCC), thereby improving the killing of tumors by immune cells
▲The mechanism of action of Zenocutuzumab (picture source: Merus official website)
The results reported by ASCO included a total of 45 patients with NRG1 fusion-positive solid tumors whose results could be evaluated.
Note: The original text has been deleted
Reference materials:
[1] Merus Presents Clinical Data on Zenocutuzumab in NRG1-fusion (NRG1+) Cancers at the American Society of Clinical Oncology (ASCO) 2021 Annual Meeting (Oral Abstract).